AI Article Synopsis
- A 7-year-old girl was diagnosed with a multifocal dysembryoplastic neuroepithelial tumor (DNT) in her brain, which recurred locally six years after an initial surgery.
- After the initial surgery, the tumor showed unexpected progression, leading to a second surgical intervention when she turned 14.
- The analysis of the second tumor specimen revealed unusual characteristics for a DNT, such as increased cellularity and atypical features, suggesting a rare form of DNT with multiple lesions and signs of growth.
Article Abstract
We report the case of a multifocal dysembryoplastic neuroepithelial tumor (DNT) in a 7-year-old girl with local tumor regrowth 6 years later. The tumor was localized in the right parietal lobe extending from the cortex into the periventricular white matter. After subtotal resection of a histopathologically confirmed DNT we observed unexpected tumor progression in long-term follow-up. Therefore, a second surgery was performed when the patient was 14 years of age. In neuropathological examination of the second specimen the tumor showed an increased cellularity and pleomorphism, microvascular proliferations, an elevated proliferative activity (MIB1-index focally up to 10%) and cellular atypia not typical for WHO grade I DNT. Furthermore, MRI studies showed additional supratentorial and infratentorial lesions which remained stable over years and are also well consistent with DNTs. Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed.
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| http://dx.doi.org/10.1111/j.1440-1789.2007.00780.x | DOI Listing |
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