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Effects of an external load on anticipatory mechanisms of handstand walking initiation in experienced gymnasts.
J Sports Sci
January 2025
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Anticipatory postural adjustments (APAs) are responsible for a successful first step execution in handstand walking. This study evaluates gymnasts' ability to adapt their APAs and stepping parameters in response to adding/removing an external load over repeated handstand walking initiation trials. Eighteen gymnasts performed five handstand walking initiation trials without load (PRE), eight trials with an external load (LOAD) and five trials with removed load (POST).
View Article and Find Full Text PDFHigh-Viability Circulating Tumor Cells Sorting From Whole Blood at Single Cell Level Using Laser-Induced Forward Transfer-Assisted Microfiltration.
Adv Sci (Weinh)
January 2025
School of Integrated Circuits, Peking University, Beijing, 100871, China.
The efficient isolation and molecular analysis of circulating tumor cells (CTCs) from whole blood at single-cell level are crucial for understanding tumor metastasis and developing personalized treatments. The viability of isolated cells is the key prerequisite for the downstream molecular analysis, especially for RNA sequencing. This study develops a laser-induced forward transfer -assisted microfiltration system (LIFT-AMFS) for high-viability CTC enrichment and retrieval from whole blood.
View Article and Find Full Text PDFATG8 in single membranes: Fresh players of endocytosis and acidic organelle quality control in cancer, neurodegeneration, and inflammation.
Biochem Biophys Res Commun
January 2025
Molecular and Biomedical Sciences, University of Adelaide, Adelaide, SA, 5005, Australia; College of Public Health and Medicine, Flinders University, Bedford Park, SA, 5042, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia. Electronic address:
Ubiquitin-like autophagy-related gene ATG8 proteins are typically associated with degradative quality control via canonical double-membrane macro-autophagosomes in the cell. ATG8 proteins have now stepped forward in non-canonical pathways in single membrane organelles. The growing interest in non-canonical ATG8 roles has been stimulated by recent links to human conditions, especially in the regulation of inflammation, neurodegeneration and cancers.
View Article and Find Full Text PDFStepping up recovery: integrating patient reported outcome measures and wearable technology for 90-day rehabilitation following total hip arthroplasty.
Arch Orthop Trauma Surg
December 2024
Department of Orthopedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Introduction: There is conflicting data in the literature regarding the clinical utility of wearable devices. This study examined the association between patient reported outcome measures (PROMs) and step and stair flight counts obtained from wearable devices in postoperative total hip arthroplasty (THA) patients.
Methods: Data was collected from a multicenter prospective longitudinal cohort study from October 2018 to February 2022.
CAR T-cells in autoimmunity: game changer or stepping stone?
Blood
December 2024
Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
The advent of chimeric antigen receptor (CAR) T-cells has revolutionized the treatment landscape for hematologic malignancies, and emerging evidence suggests their potential in autoimmune diseases (AIDs). This article examines the early successes and future implications of B-cell-targeting CAR T-cell therapy in AIDs. Initial applications, particularly in refractory systemic lupus erythematosus (SLE), have demonstrated significant and durable clinical remissions, with accompanying evaluation of the immune system suggesting a so-called "reset" of innate inflammation and adaptive autoimmunity.
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