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Metabolic differentiation of brushtail possum populations resistant and susceptible to plant toxins revealed via differential gene expression.
J Comp Physiol B
November 2024
Wildlife and Ecology, School of Natural Sciences, Massey University, Private Bag 11-222, Palmerston North, New Zealand.
The Australian brushtail possum (Trichosurus vulpecula) is adapted to a wide range of food plants across its range and is exposed to numerous physiological challenges. Populations that are resistant to the plant toxin sodium fluoroacetate are of particular interest as this compound has been used since the 1940s for vertebrate pest management around the world. Candidate gene identification is an important first step in understanding how spatial populations have responded to local selection resulting in local physiological divergence.
View Article and Find Full Text PDFParadigm Shift: Major Role of Ion-Pairing-Dependent Size Exclusion Effects in Bottom-Up Proteomics Reversed-Phase Peptide Separations.
Anal Chem
June 2024
Manitoba Centre for Proteomics and Systems Biology, 799 JBRC, 715 McDermot Avenue, Winnipeg R3E 3P4, Canada.
Can reversed-phase peptide retention be the same for C8 and C18 columns? or increase for otherwise identical columns with a smaller surface area? Can replacing trifluoroacetic acid (TFA) with formic acid (FA) improve the peak shape? According to our common understanding of peptide chromatography, absolutely not. Surprisingly, a thorough comparison of the peptide separation selectivity of 100 and 120 Å fully porous C18 sorbents to maximize the performance of our in-house proteomics LC-MS/MS setup revealed an unexpectedly higher peptide retentivity for a wider pore packing material, despite it having a smaller surface area. Concurrently, the observed increase in peptide retention─which drives variation in separation selectivity between 100 and 120 Å pore size materials─was more pronounced for smaller peptides.
View Article and Find Full Text PDFHydrothermal Destruction and Defluorination of Trifluoroacetic Acid (TFA).
Environ Sci Technol
May 2024
Mechanical Engineering Department, University of Washington, Seattle, Washington 98195, United States.
Per- and polyfluoroalkyl substances (PFAS) have received increased attention due to their environmental prevalence and threat to public health. Trifluoroacetic acid (TFA) is an ultrashort-chain PFAS and the simplest perfluorocarboxylic acid (PFCA). While the US EPA does not currently regulate TFA, its chemical similarity to other PFCAs and its simple molecular structure make it a suitable model compound for studying the transformation of PFAS.
View Article and Find Full Text PDFHydrolase-catalyzed kinetic resolution is a well-established biocatalytic process. However, the computational tools that predict favorable enzyme scaffolds for separating a racemic substrate mixture are underdeveloped. To address this challenge, we trained a deep learning framework, EnzyKR, to automate the selection of hydrolases for stereoselective biocatalysis.
View Article and Find Full Text PDFWavelength-Dependent UV-LED Photolysis of Fluorinated Pesticides and Pharmaceuticals.
Environ Sci Technol
April 2023
Department of Civil, Environmental, and Geo- Engineering, University of Minnesota, 500 Pillsbury Dr. SE, Minneapolis, Minnesota 55455, United States.
The wavelength dependence of photoproduct formation and quantum yields was evaluated for fluorinated pesticides and pharmaceuticals using UV-light emitting diodes (LEDs) with 255, 275, 308, 365, and 405 nm peak wavelengths. The fluorinated compounds chosen were saflufenacil, penoxsulam, sulfoxaflor, fluoxetine, 4-nitro-3-trifluoromethylphenol (TFM), florasulam, voriconazole, and favipiravir, covering key fluorine motifs (benzylic-CF, heteroaromatic-CF, aryl-F, and heteroaromatic-F). Quantum yields for the compounds were consistently higher for UV-C as compared to UV-A wavelengths and did not show the same trend as molar absorptivity.
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