Radiother Oncol
Department of Radiation Oncology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Published: November 2007
Background And Purpose: Currently, inverse planning for intensity-modulated radiotherapy (IMRT) can be a time-consuming trial and error process. This is because many planning objectives are inherently contradictory and cannot reach their individual optimum all at the same time. Therefore in clinical practice the potential of IMRT cannot be fully exploited for all patients. Multicriteria (multiobjective) optimization combined with interactive plan navigation is a promising approach to overcome these problems.
Patients And Methods: We developed a new inverse planning system called "Multicriteria Interactive Radiotherapy Assistant (MIRA)". The optimization result is a database of patient specific, Pareto-optimal plan proposals. The database is explored with an intuitive user interface that utilizes both a new interactive element for plan navigation and familiar dose visualizations in form of DVH and isodose projections. Two clinical test cases, one paraspinal meningioma case and one prostate case, were optimized using MIRA and compared with the clinically approved planning program KonRad.
Results: Generating the databases required no user interaction and took approx. 2-3h per case. The interactive exploration required only a few minutes until the best plan was identified, resulting in a significant reduction of human planning time. The achievable plan quality was comparable to KonRad with the additional benefit of having plan alternatives at hand to perform a sensitivity analysis or to decide for a different clinical compromise.
Conclusions: The MIRA system provides a complete database and interactive exploration of the solution space in real time. Hence, it is ideally suited for the inherently multicriterial problem of inverse IMRT treatment planning.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.radonc.2007.06.020 | DOI Listing |
Gland Surg
December 2024
Department of Breast Oncology, Hainan Cancer Hospital, Haikou, China.
Background: Breast cancer-related lymphedema (BCRL) is one of the common complications after breast cancer surgery. It can easily lead to limb swelling, deformation and upper limb dysfunction, which has a serious impact on the physical and mental health and quality of life of patients. Previous studies have mostly used statistical methods such as linear regression and logistic regression to analyze the influencing factors, but all of them have certain limitations.
View Article and Find Full Text PDFStrahlenther Onkol
January 2025
Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Purpose: Due to the need for high-quality teaching, we present a new blended learning concept combining digital modules, interactive seminars, and clinical experience. Furthermore, we evaluated its acceptance among students.
Methods: A new concept for teaching was applied to the radiotherapy module and made available via the Hannover Medical School (MHH) learning management system as part of a blended learning concept with educational films, multimedia learning modules, online seminars, and onsite practical training.
Sci Rep
January 2025
Department of Radiotherapy Oncology, The Fourth Hospital of Hebei Medical University, No. 169, Tianshan Street, Hebei, Shijiazhuang, 050035, Hebei Province, China.
Breast cancer is the most common malignant tumor in the world, and its metastasis is the main cause of death in breast cancer patients. However, the differences between primary breast cancer tissue and lymphatic node, bone, and brain metastases at the single-cell level are not fully understood. We analyzed the microenvironment heterogeneity in samples of primary breast cancer (n = 4), breast cancer lymphatic node metastasis (n = 4), breast cancer brain metastasis (n = 3), and breast cancer bone metastasis (n = 2) using single-cell sequencing data from the GEO database.
View Article and Find Full Text PDFCancer Biol Ther
December 2025
Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, People's Republic of China.
Objective: The purpose of this research was to investigate the role of extracellular vesicles derived from lung cancer stem cells (lung CSCs-EVs) in lung cancer and to explore their potential mechanisms.
Methods: Lung CSCs were first isolated and verified using flow cytometry and RT-qPCR assays. Lung CSCs-EVs were extracted through ultracentrifugation and further characterized using transmission electron microscopy and Western blotting.
Mol Pharm
January 2025
College of Life Science and Technology, Changchun University of Science and Technology, 7089 Satellite Road, Changchun 130022, China.
Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy and chemotherapy, often lack specificity, leading to collateral damage to normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, and elevated ATP levels factors that collectively promote tumor growth and metastasis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.