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Identification of N-phenyl-N-(quinolin-4-yl) amino carboxylic acids as URAT1 inhibitors with hypouricemic effects.
Bioorg Med Chem Lett
March 2025
Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; State Key Laboratory of Digestive Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:
Urate transporter 1 (URAT1) is a therapeutic target for the treatment of hyperuricemia and gout. However, the application of currently marketed URAT1 inhibitors is hampered by insufficient efficacy and poor safety profiles. A series of N-phenyl-N-(quinolin-4-yl) amino carboxylic acids were designed by adopting strategies of molecular hybridization, scaffold hopping, and functional variation.
View Article and Find Full Text PDFAnnual change in eGFR in renal hypouricemia: a retrospective pilot study.
Clin Exp Nephrol
October 2024
Department of Cardiology, National Hospital Organization, Yonago Medical Center, Yonago, Japan.
Article Synopsis
- Some people with a condition called renal hypouricemia (RHU) have very low levels of uric acid, which might be linked to kidney problems, but we don’t know much about how it affects kidney function.
- A study looked at 13 RHU patients over about 5.5 years and found that their kidney function (eGFR) didn't get worse, while it did for others without RHU.
- RHU patients with different types of genetic mutations also showed no major differences in how their kidney function changed over time.
Drug-Induced Hypouricemia.
Drug Saf
September 2024
Intensive Care, Department of Intensive Care, Sahloul Hospital, University of Sousse, Sousse, Tunisia.
Hypouricemia is defined as a serum uric acid concentration of ≤ 2.0 mg/dL or 119 μmol/L. Hypouricemia may occur secondarily to a number of underlying conditions, including severe hepatocellular disease, neoplasia, defective renal tubular reabsorption of uric acid, inherited metabolic defect in purine metabolism, and drugs.
View Article and Find Full Text PDFRare renal proximal tubular dysfunctions in primary biliary cholangitis.
Ren Fail
December 2024
Department of Nephrology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Introduction: Renal involvement of primary biliary cholangitis (PBC) usually presents as distal renal tubular acidosis. Proximal tubular (PT) dysfunctions in PBC were rarely reported with unclear clinicopathological characteristics and renal prognosis.
Methods: We identified 11 cases of PBC with PT dysfunctions (PBC-PT).
Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise.
World J Nephrol
May 2023
Department of Pediatrics, Kumamoto University, Kumamoto 8608556, Japan.
Background: There are two known types of exercise-induced acute renal failure. One is the long-known myoglobinuria-induced acute renal failure due to severe rhabdomyolysis, and the other is the recently recognized non-myoglobinuria-induced acute renal failure with mild rhabdomyolysis. Exercise-induced acute renal failure was first reported in 1982.
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