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Composition and changes of blood microbiota in adult patients with community-acquired sepsis: A study from bench to bedside.
Front Cell Infect Microbiol
January 2023
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
Background: Characteristics of the blood microbiota among adult patients with community-acquired sepsis are poorly understood. Our aim was to analyze the composition of blood microbiota in adult patients with community-acquired sepsis, and correlate changes with non-septic control patients.
Methods: A prospective observational study was carried out by including adult patients hospitalized for community-acquired sepsis at our center between January and November 2019, by random selection from a pool of eligible patients.
Outcomes of systemic bivalirudin and sodium bicarbonate purge solution for Impella 5.5.
Artif Organs
February 2023
Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Background: Impella 5.5 (Abiomed; Danvers, MA) (IMP5) is a commonly used, surgically implanted, tMCS device that requires systemic anticoagulation and purge solution to avoid pump failure. To avoid heparin-induced thrombocytopenia (HIT) from unfractionated heparin (UFH) use, our program has explored the utility of bivalirudin (BIV) for systemic anticoagulation and sodium bicarbonate-dextrose purge solution (SBPS) in IMP5.
View Article and Find Full Text PDFOutcomes of systemic anticoagulation with bivalirudin for Impella 5.0.
Int J Artif Organs
October 2021
Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Temporary mechanical circulatory support (tMCS) devices are used for the management of cardiogenic shock. The Impella 5.0 (Abiomed; Danvers, MA) (IMP5) is a commonly used, surgically implanted, tMCS device that requires systemic anticoagulation and purge solution to avoid pump failure.
View Article and Find Full Text PDFRational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.
J Med Chem
December 2020
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.
To validate the hypothesis that Tyr748 is a crucial residue to aid the discovery of highly selective phosphodiesterase 8A (PDE8A) inhibitors, we identified a series of 2-chloroadenine derivatives based on the hit clofarabine. Structure-based design targeting Tyr748 in PDE8 resulted in the lead compound (IC = 0.010 μM) with high selectivity with a reasonable druglike profile.
View Article and Find Full Text PDFDiscovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.
J Med Chem
March 2020
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China.
To validate PDE4 inhibitors as novel therapeutic agents against vascular dementia (VaD), 25 derivatives were discovered from the natural inhibitor α-mangostin (IC = 1.31 μM). Hit-to-lead optimization identified a novel and selective PDE4 inhibitor (IC = 17 nM), which adopted a different binding pattern from PDE4 inhibitors roflumilast and rolipram.
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