Although conventional breast-imaging techniques routinely include mammography and ultrasound, growing interest in other approaches, perhaps most notably MR imaging, has drawn increasing attention to exploiting the anatomic and physiologic basis for understanding breast cancer. Nuclear medicine techniques have been applied in several circumstances with the intent of approaching or defining a role for molecular imaging, exemplified by the use of F-18 fluorodeoxyglucose and positron emission tomography. Other techniques, including exploitation of additional components of the electromagnetic spectrum, have provided novel concepts that may ripen into clinical use.
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Case report: Illustrating associated malignancies in Paget's disease using contrast-enhanced mammography.
Front Oncol
January 2025
Breast Imaging Division, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy.
Introduction: The following presentation explores the diagnostic potential of Contrast-Enhanced Mammography (CEM) in evaluating and managing Paget's Disease (PD) of the breast, particularly as an alternative or complementary tool to Magnetic Resonance Imaging (MRI) in cases where MRI is contraindicated or inconclusive.
Clinical Cases: Two clinical cases of PD diagnosed at our Breast Imaging Division between January and May 2024 were analyzed using CEM. These cases involved imaging techniques, including Digital Mammography (DM), Breast Ultrasound (US), MRI and CEM, alongside histopathological confirmation through nipple-areolar complex (NAC) punch biopsies.
Active Monitoring With or Without Endocrine Therapy for Low-Risk Ductal Carcinoma In Situ: The COMET Randomized Clinical Trial.
JAMA
December 2024
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Importance: Active monitoring for low-risk ductal carcinoma in situ (DCIS) of the breast has been proposed as an alternative to guideline-concordant care, but the safety of this approach is unknown.
Objective: To compare rates of invasive cancer in patients with low-risk DCIS receiving active monitoring vs guideline-concordant care.
Design, Setting, And Participants: Prospective, randomized noninferiority trial enrolling 995 women aged 40 years or older with a new diagnosis of hormone receptor-positive grade 1 or grade 2 DCIS without invasive cancer at 100 US Alliance Cancer Cooperative Group clinical trial sites from 2017 to 2023.
Diagnostic performance of simultaneous multislice diffusion-weighted imaging in differentiating breast lesions: a systematic review and meta-analysis.
Br J Radiol
February 2025
Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objectives: To investigate the diagnostic performance of simultaneous multislice diffusion-weighted imaging (SMS-DWI) in differentiating malignant and benign breast lesions, and compare it with conventional single shot and readout segmented echo planar imaging without the SMS technique.
Methods: The literature search was performed in PubMed, Embase, and Web of Science to identify comparative studies reporting the diagnostic performance of SMS-DWI and conventional DWI in patients with breast lesions. Histopathological analysis was used as a reference standard for malignant breast lesions.
[Prospective multicenter cohort study on breast cancer screening using an automated breast ultrasound with remote reading].
Zhonghua Zhong Liu Za Zhi
November 2024
Department of Ultrasound, Xijing Hospital, the First Affiliated Hospital of Air Force Medical University, Xi'an710032, China.
To construct a remote screening network for breast cancer based on automated breast ultrasound (ABUS) and explore the value of ABUS with remote reading for breast cancer screening. We constructed a remote breast cancer screening network including one remote reading center and 48 image-acquisition centers. We recruited women to participate in breast cancer screening at one of these image-acquisition centers from January 2021 to January 2023.
View Article and Find Full Text PDFCalculating future 10-year breast cancer risks in risk-adapted surveillance: A method comparison and application in clinical practice.
Cancer Prev Res (Phila)
November 2024
Leipzig University, Leipzig, Germany.
Article Synopsis
- The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a system for monitoring women at high risk for breast cancer, recommending annual screenings using the BOADICEA risk model for those with a 10-year risk of 5% or more.
- Women with a family history of breast cancer may qualify for increased surveillance as they age, even if their initial risk doesn’t meet the threshold.
- Two methods were compared for determining when a woman's risk increases: the 'prediction by aging pedigree' (AP) which tracks family history over time, and a simpler 'conditional probability' (CP) approach, which estimates future risks based on initial assessments; the CP method was found to be
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