Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.

Bioorg Med Chem Lett

Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, PR China.

Published: November 2007

Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.

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http://dx.doi.org/10.1016/j.bmcl.2007.09.033DOI Listing

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