The ipsipedal application of UHSK leads to a decisive increase of recanalisation. The fibrinolyticum will be brought in a greater quantity to the thrombotic region. The adjuvant supramalleolar compression and the increase of volume seems to be beneficial. The promising results of thrombolysis at elder thrombosis justify a late fibrinolysis, which is profitable too, for patients with early postoperative thrombosis at the end of the first wound healing phase.
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BMC Pediatr
December 2024
Department of Intensive Care Unit, Hangzhou Women's Hospital, Hangzhou, 310016, Zhejiang, China.
Background: To compare the impact of two different lipid emulsions, specifically a soybean oil-based emulsion and a multiple oil emulsion (soybean oil, medium-chain triglycerides, olive oil, and fish oil, SMOF), on serum metabolites of very low birth weight (VLBW) infants using untargeted metabolomics analysis.
Methods: A comparative study was conducted on 25 VLBW infants hospitalized in neonatal intensive care units (NICU) of Hangzhou Women's Hospital in 2023. The infants were divided into the SMOF group (13 cases) and the soybean oil group (12 cases) based on the type of lipid emulsion used during parenteral nutrition.
Zhongguo Zhong Yao Za Zhi
October 2024
Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine Guangzhou 510095, China Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Research and Development Guangzhou 510095, China.
This study aims to compare the effects and mechanisms of the standard decoction and formula granules of Paeoniae Radix Rubra in regulating the metabolism in the rat model of heat toxin and blood stasis. SD rats were randomized into control, model, standard decoction, and formula granules groups. After 14 days of administration, the rats in the latter three groups were subjected to subcutaneous injection with carrageenan and intraperitoneal injection with bacterial lipopolysaccharide for the modeling of heat toxin and blood stasis.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
October 2024
School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co., Ltd. Linyi 273400, China.
This study aims to explore the therapeutic effect of Yuzhi Zhixue Granules on polycystic ovary syndrome(PCOS) in rats and explain the underlying mechanism by metabolomics. Rats were randomized into normal, model, low-, medium-, and high-dose(0.5, 1.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
September 2024
School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS), UNIFI software, and a self-built compound library of Longxuejie Capsules were employed to analyze the pharmacodynamic substances of Longxuejie Capsules and the metabolites in rats. The methanol extracts of capsule contents as well as the plasma, urine, and fecal metabolites of rats after drug administration were prepared. Data were collected in both positive and negative MS~E Continuum scan modes via UPLC-Q-TOF-MS.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
"P.U.M.A.", Platform for Unique Model Application, Department of Pharmacy, Wroclaw Medical University, Borowska 211, 50-534 Wroclaw, Poland.
The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study evaluates the in vitro effectiveness of antiseptic and lavage solutions-including polyhexanide, povidone-iodine, low-concentrated hypochlorite, Ringer's solution, and saline-against , MRSA, , , , and . Using microplate models (Minimum Inhibitory Concentration, Minimum Biofilm Eradication Concentration, and Biofilm-Oriented Antiseptic Test assays), flow-based models (Bioflux system), and surfaces relevant to orthopedic implants (e.
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