Purpose: Perillyl alcohol (POH) is a naturally occurring lipid with preclinical activity against mammary carcinomas. We conducted a phase II multi-institutional study of oral POH administered four times daily in women with advanced treatment-refractory breast cancer.
Methods: Eligible women were treated with POH four times daily at 1,200-1,500 mg m(-2) dose(-1) on a 28-day cycle. Patients tolerating 1,200 mg m(-2) day(-1) four times daily after one cycle were dose-escalated to 1,500 mg/m(2). The primary endpoint was 1-year freedom-from-progression (FFP) rate. Secondary endpoints were response rate, tolerability and correlative evaluations.
Results: Twenty-nine cycles of POH were administered to 14 women. Three patients were dose-escalated to 1,500 mg/m(2). Grade 1 and grade 2 gastrointestinal effects and fatigue were predominant toxicities. Of seven patients receiving up to one cycle, three stopped therapy due to intolerance. Only two patients received more than two cycles, with disease stabilization of 3 and 8 months. Thirteen patients were evaluable for response. One-year FFP rate was zero. No objective responses were seen. The median time to progression was 35 days (95% CI, 29-123 days). Median overall survival was 389 days (95% CI, 202-776 days). Pharmacokinetic parameters were similar to previous investigations. The ability to correlate plasma TGF-beta1 levels with outcome was limited by lack of clinical benefit and inter- and intra-patient variability.
Conclusions: Enrollment was suspended short of planned accrual because of lack of response and poor tolerance to POH. This regimen does not appear to provide benefit in advanced treatment-refractory breast carcinoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00280-007-0585-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A harmonized river-ocean coupled database for the northern Gulf of Mexico.
Sci Data
December 2024
Department of Mathematics, Texas A&M University, College Station, TX, 77843, USA.
The northern Gulf of Mexico (nGoM) receives water from over 50 rivers which are highly influenced by humans and include the largest river in the United States, the Mississippi River. To support large-scale data-driven research centered on the dynamic river-ocean system in the region, this study consolidated hydrogeochemical river and ocean data from across the nGoM. In particular, we harmonized 35 chemical solute parameters from 54 rivers and incorporated river discharge data to derive daily solute concentration and flux estimates throughout the nGoM.
View Article and Find Full Text PDFPreventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice.
NPJ Sci Food
December 2024
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka, Japan.
In a series of studies on blood-brain barrier transportable peptides, a soybean dipeptide, Tyr-Pro, penetrated the mouse brain parenchyma after oral intake and improved short and long memory impairment in acute Alzheimer's model mice. Here, we aimed to clarify the anti-dementia effects of this peptide administered to SAMP8 mice prior to dementia onset. At the end of the 25-week protocol in 16-week-old SAMP8 mice, Tyr-Pro (10 mg/kg/day) significantly improved the reduced spatial learning ability compared with that in the control and amino acid (Tyr + Pro) groups as indicated by the results of Morris water maze tests conducted for five consecutive days.
View Article and Find Full Text PDFPollination Across the Diel Cycle: A Global Meta-Analysis.
Ecol Lett
January 2025
Department of Biology, Lund University, Lund, Sweden.
The daily transition between day and night, known as the diel cycle, is characterised by significant shifts in environmental conditions and biological activity, both of which can affect crucial ecosystem functions like pollination. Despite over six decades of research into whether pollination varies between day and night, consensus remains elusive. We compiled the evidence of diel pollination from 135 studies with pollinator exclusion experiments involving 139 angiosperms.
View Article and Find Full Text PDFMultiuser design of an architecture for social robots in education: teachers, students, and researchers perspectives.
Front Robot AI
December 2024
Robot Learning Laboratory, Instituto de Ciências Matemáticas e de Computação (ICMC), University of São Paulo (USP), SãoCarlos, Brazil.
Research on social assistive robots in education faces many challenges that extend beyond technical issues. On one hand, hardware and software limitations, such as algorithm accuracy in real-world applications, render this approach difficult for daily use. On the other hand, there are human factors that need addressing as well, such as student motivations and expectations toward the robot, teachers' time management and lack of knowledge to deal with such technologies, and effective communication between experimenters and stakeholders.
View Article and Find Full Text PDFDepression and emotion regulation strategy use moderate age-related attentional positivity bias.
Front Psychol
December 2024
Center for Cognitive Neuroscience, Duke University, Durham, NC, United States.
Effective emotion regulation is critical for maintaining emotional health in the face of adverse events that accumulate over the lifespan. These abilities are thought to be generally maintained in older adults, accompanied by the emergence of attentional biases to positive information. Such age-related positivity biases, however, are not always reported and may be moderated by individual differences in affective vulnerabilities and competencies, such as those related to dispositional negative affect and emotion regulation styles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!