Perhaps the greatest recent controversy in the medical management of complex neurologic and neurosurgical patients has been the defining of the optimal care arena. Despite some early skepticism and measured recognition by the ICU community, neurosciences critical care has grown into a well-recognized subspecialty. Within this environment, the diverse expertise of surgeons, neurologists, and anesthesiologists come together to define best therapeutic strategies. Two neurologic disease states that, in particular, continue to elicit expansive interdisciplinary debate are spontaneous intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.anclin.2007.05.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer's disease.
J Clin Invest
January 2025
Growth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Posttranslational modification (PTM) of the amyloid precursor protein (APP) plays a critical role in Alzheimer's disease (AD). Recent evidence reveals that lactylation modification, as a novel PTM, is implicated in the occurrence and development of AD. However, whether and how APP lactylation contributes to both the pathogenesis and cognitive function in AD remains unknown.
View Article and Find Full Text PDFA systematic review of the association between insulin resistance surrogate indices and bone mineral density.
Front Endocrinol (Lausanne)
January 2025
Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: The relationship of insulin resistance with bone mineral density (BMD) remains unclear, offering an opportunity for novel indices to shed light on the matter. The aim of this review was to evaluate the association between surrogate indices of insulin resistance and BMD.
Methods: A systematic review was conducted to evaluate observational studies that examined the relationship between insulin resistance surrogate indices and BMD in adults.
Skeletal interoception and prospective application in biomaterials for bone regeneration.
Bone Res
January 2025
Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China.
Accumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metabolic homeostasis related to bone health. This review provides a comprehensive analysis of how skeletal interoception influences bone homeostasis, delving into the complex interplay between the nervous system and skeletal system. One key focus of the review is the role of various factors such as prostaglandin E2 (PGE2) in skeletal health via skeletal interoception.
View Article and Find Full Text PDFPrediction of good neurological outcome after return of circulation following paediatric cardiac arrest: a systematic review and meta-analysis.
Resuscitation
December 2024
Department of Critical Care Medicine, Hospital for Sick Children, Department of Paediatrics, University of Toronto, Neurosciences and Mental Health Program, Research Institute Toronto, ON, Canada.
Aim: To evaluate the ability of blood-biomarkers, clinical examination, electrophysiology, or neuroimaging, assessed within 14 days from return of circulation to predict good neurological outcome in children following out- or in-hospital cardiac arrest.
Methods: Medline, EMBASE and Cochrane Trials databases were searched (2010-2023). Sensitivity and false positive rates (FPR) for good neurological outcome (defined as either 'no, mild, moderate disability or minimal change from baseline') in paediatric survivors were calculated for each predictor.
REINTEGRATION INTO WORK AFTER TRAUMATIC BRACHIAL PLEXUS INJURIES: A SELECTIVE LITERATURE REVIEW ON EXPERIENCES FROM VARIOUS GLOBAL REGIONS.
World Neurosurg
December 2024
Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart, Germany; Institute of Industrial Manufacturing and Management, University of Stuttgart, Germany.
Article Synopsis
- Thousands of young adults experience traumatic brachial plexus injuries (TBPIs), which often result in permanent disabilities and difficulties returning to work, creating social and economic challenges.
- The study aims to assess return-to-work rates after TBPI and compare outcomes between healthcare systems in Germany, Serbia, and the UK.
- Preliminary findings suggest that about 60% of TBPI patients manage to return to work, but often in different occupational roles, indicating ongoing challenges in patient reintegration despite variations in healthcare support.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!