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Introduction: Healthcare provider burnout is highly prevalent and has negative consequences. However, many healthcare workers in LMICs, including Nepal, rarely recognize or ameliorate it. This problem is worse in rural settings.
View Article and Find Full Text PDFEHM: Exploring dynamic alignment and hierarchical clustering in unsupervised domain adaptation via high-order moment-guided contrastive learning.
Neural Netw
January 2025
College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou, 310027, China. Electronic address:
Unsupervised domain adaptation (UDA) aims to annotate unlabeled target domain samples using transferable knowledge learned from the labeled source domain. Optimal transport (OT) is a widely adopted probability metric in transfer learning for quantifying domain discrepancy. However, many existing OT-based UDA methods usually employ an entropic regularization term to solve the OT optimization problem, inevitably resulting in a biased estimation of domain discrepancy.
View Article and Find Full Text PDFDesign of a light and Ca switchable organic-peptide hybrid.
Proc Natl Acad Sci U S A
February 2025
SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 16419, Republic of Korea.
The design of organic-peptide hybrids has the potential to combine our vast knowledge of protein design with small molecule engineering to create hybrid structures with complex functions. Here, we describe the computational design of a photoswitchable Ca-binding organic-peptide hybrid. The designed molecule, designated Ca-binding switch (CaBS), combines an EF-hand motif from classical Ca-binding proteins such as calmodulin with a photoswitchable group that can be reversibly isomerized between a spiropyran (SP) and merocyanine (MC) state in response to different wavelengths of light.
View Article and Find Full Text PDFViews of speech pathology educators on a learning resource for cognitive-communication disorders: a user survey of TBIBank Grand Rounds.
Brain Impair
January 2025
Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Background Cognitive-communication disorders are highly prevalent after traumatic brain injury and have significant impacts on rehabilitation outcomes. TBIBank Grand Rounds was developed as an online multimedia resource to support clinical education about cognitive-communication disorders. The objective of this study was to survey speech pathology educators to establish their views towards TBIBank Grand Rounds.
View Article and Find Full Text PDFMining microbial and metabolic dark matter in extreme environments: a roadmap for harnessing the power of multi-omics data.
Adv Biotechnol (Singap)
August 2024
State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Stress Biology and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, PR China.
Extreme environments such as hyperarid, hypersaline, hyperthermal environments, and the deep sea harbor diverse microbial communities, which are specially adapted to extreme conditions and are known as extremophiles. These extremophilic organisms have developed unique survival strategies, making them ideal models for studying microbial diversity, evolution, and adaptation to adversity. They also play critical roles in biogeochemical cycles.
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