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Immunological and protective evaluation of purE/purK gene-deletion mutant of Brucella melitensis M5 strain.
Microb Pathog
January 2025
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yujinxiang Street 573, Changchun, Jilin, 130122, China. Electronic address:
Brucellosis is listed by the World Health Organization as one of the seven most neglected global zoonotic diseases. A live-attenuated vaccine is still the main strategy used to prevent the spread of brucellosis. In this study, we constructed a two-gene (purE and purK)-deletion vaccine in Brucella melitensis vaccine strain M5 with homologous recombination.
View Article and Find Full Text PDFA Case Report of Meningitis Caused by Biovar 3.
Infect Drug Resist
December 2024
State International Joint Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, People's Republic of China.
Background: Brucellosis, a major endemic disease in northern China, is contracted by zoonosis of . We report a case of meningitis caused by biovar 3.
Case Presentation: A 46-year-old man was hospitalized at a local medical facility due to symptoms of fever, soreness, and weakness on April 16, 2021.
Evaluation of three serological tests for the diagnosis of Brucella suis in dogs using Bayesian latent class analysis.
Prev Vet Med
December 2024
Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, Victoria 3010, Australia.
Article Synopsis
- Brucella suis infection in dogs is a growing concern globally, necessitating specific management due to zoonotic and animal welfare risks.
- This study evaluated the effectiveness of three serological tests (RBRPT, CFT, C-ELISA) on 989 dog serum samples to diagnose Brucella suis, using advanced statistical techniques to interpret results.
- Results showed that while all tests are useful for detecting B. suis antibodies, they should not be used alone; their accuracy depends on the likelihood of the disease based on the dog's background and clinical signs.
Development of a RPA-CRISPR/Cas12a based rapid visual detection assay for Porcine Parvovirus 7.
Front Vet Sci
September 2024
College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Introduction: Porcine Parvovirus (PPV) is a significant pathogen in the pig industry, with eight genotypes, including PPV7, identified since its emergence in 2016. Co-infections with viruses such as Porcine Circovirus 2 (PCV2) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) pose serious risks to swine health. Thus, there is an urgent need for rapid, sensitive, and specific detection methods suitable for use in field settings or laboratories with limited resources.
View Article and Find Full Text PDFClinical characteristic, management, and outcomes of cervical spinal brucellosis: a retrospective cohort study over 1-year postoperative follow-up.
J Orthop Surg Res
June 2024
Department of Spine Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu, China.
Article Synopsis
- * Neck pain and limb paralysis were the most common symptoms, with rapid disease progression and the C6-7 spinal segment being most frequently affected.
- * Surgical intervention (debridement and fusion) led to significant improvements in pain and functional scores, while inflammatory markers returned to normal levels within three months, though bacterial culture tests showed low positivity rates.
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