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Epicatechin attenuates emamectin benzoate-induced liver injury in grass carp by activating Nrf2/GPX4 signaling pathway.
Fish Shellfish Immunol
January 2025
College of Animal Science and Technology, Jilin Agriculture Science and Technology University, Jilin City, China. Electronic address:
Emamectin benzoate (EMB) is an antibiotic insecticide pesticide modified from avermectin. In the current study, we performed an in-depth investigation of the protective effects of epicatechin on EMB-induced liver injury in common carps. The carps were cultured in an aquatic environment containing 2.
View Article and Find Full Text PDFBougainvillea glabra-mediated synthesis of Zr₃O and chitosan-coated zirconium oxide nanoparticles: Multifunctional antibacterial and anticancer agents with enhanced biocompatibility.
Int J Biol Macromol
January 2025
Department of Chemistry, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India; Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India. Electronic address:
The effectiveness and safety of nanomaterials (NMs) are essential for their use in healthcare. This study focuses on creating NPs with multifunctional antibacterial and anticancer properties to combat bacterial infections and cancer disease more effectively than traditional antibiotics. This study investigates the synthesis of ZrO and chitosan (ch) coated zirconium oxide nanoparticles (chZrO NPs) using Bougainvillea glabra (B.
View Article and Find Full Text PDFPathway of typical β-Lactam antibiotics degradation by black soldier fly and response characteristic of its intestinal microbes.
Bioresour Technol
January 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan 430062 China. Electronic address:
To effectively address the contamination caused by antibiotic misuse, this study was conducted to enhance the removal of amoxicillin (AMX) and penicillin sodium (PEN) by incorporating black soldier fly larvae (BSFL). The results showed that BSFL increased the degradation rates of AMX and PEN to 71.00 % and 80.
View Article and Find Full Text PDFSynthesis of tetra-substituted thiophene derivatives as potential Hits combating antibiotic resistant bacteria ESKAPE.
Bioorg Chem
January 2025
Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt.
The escalating prevalence of antibiotic-resistant bacteria has led to a serious global public health problem; therefore, there is an urgent need for the development of structurally innovative antibacterial agents. In our study, different series of tetra-substituted thiophene derivatives were designed and synthesized by multi-component reactions (MCRs) in moderate to excellent yields. Some of the designed final compounds were synthesized by both microwave assisted method and traditional synthesis.
View Article and Find Full Text PDFClinical impacts of utilizing ceftriaxone and metronidazole versus piperacillin/tazobactam in patients diagnosed with complicated diverticulitis.
Am J Surg
January 2025
Department of Pharmacy, Mayo Clinic Health System, Eau Claire, WI, USA.
Background: The optimal antibiotic regimen to empirically treat complicated diverticulitis has not been well established in guidelines.
Methods: A 5-year retrospective cohort study was conducted with 322 patients admitted to Mayo Clinic hospitals for complicated diverticulitis. Outcomes for 89 patients treated with ceftriaxone and metronidazole were compared to 233 patients treated with piperacillin/tazobactam.
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