Background: Bariatric surgery is the only treatment that can provide effective long-term weight loss for morbid obesity. However, animal models of bariatric surgery have not yet been well established. The aims of this study were to establish an obese rat model of gastric banding and to determine whether the model would replicate the procedure of human gastric banding in terms of weight loss and metabolic parameters.
Methods: 27 male Zucker fatty rats were divided into 3 groups: the sham-operated control, gastric banding, and diet treatment groups. They were followed for 8 weeks after surgery, and their body weight change, cumulative food intake and metabolic parameters were examined.
Results: For the sham-operated control, gastric banding, and diet treatment groups, the mean body weights were 644 +/- 28 g, 511 +/- 77 g, and 339 +/- 15 g; % change of weight at 8 weeks after operaion were +63.7 +/- 8.3%, +33.2 +/- 20%, -12.0 +/- 2.0%, respectively. Absolute weekly food intake amounts were 233.8 +/- 38.1 g, 157.3 +/- 64 g, 80 g, and cumulative food intakes were 1862 +/- 111 g, 1258 +/- 375 g and 640 g, respectively. The gastric banding rats showed significant decreases in weight gain, % change of weight, absolute weekly food intake, and cumulative food intake compared to sham-operated control rats (P < 0.05). The banding group also had lower levels of all metabolic parameters compared with controls (P < 0.01), and these levels were equal to those of the diet-treated group.
Conclusion: The present study provides a new animal model of gastric banding using obese rats. This model may be useful in research on the biochemical and molecular mechanisms of morbid obesity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11695-007-9123-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Outcomes of Metabolic and Bariatric Surgery in Patients with Inflammatory Bowel Disease: A Long-Term Retrospective Analysis.
J Clin Med
January 2025
Division of General Surgery, Tel Aviv Sourasky Medical Center, 6 Weizman St., Tel Aviv 6423906, Israel.
: Metabolic and bariatric surgery (MBS) is a well-established treatment for severe obesity, yet its effects in patients with inflammatory bowel disease (IBD) are not well understood. MBS in this population presents unique challenges, including the potential for exacerbating inflammatory disease activity and causing complications such as malnutrition and medication malabsorption. This study aims to assess the long-term outcomes of MBS in IBD patients, focusing on both metabolic outcomes and its impact on the course of IBD.
View Article and Find Full Text PDFThromboembolic prophylaxis in bariatric and metabolic surgery: state-of-the-art according to the results of a nationwide registry study.
Updates Surg
January 2025
Department of General, Abdominal and Pediatric Surgery, SRH Municipal Hospital, Straße des Friedens 122, 07548, Gera, Germany.
The present study employed a large scaled multicenter nationwide study data analysis to elucidate the impact of thromboembolism prophylaxis (TEP) in the context of bariatric and metabolic surgery and to investigate the peri- and postoperative complications associated with TEP. A total of 63,909 patients who underwent primary bariatric surgery between 2005 and 2020 were included in the analysis. The data were collected prospectively and multicentrically in the German Bariatric Surgery Registry (GBSR) and subsequently analyzed retrospectively.
View Article and Find Full Text PDFLong-term effect of Roux-en-Y gastric bypass versus sleeve gastrectomy on reflux and Barrett's oesophagus: a randomized controlled trial.
ANZ J Surg
January 2025
Department of Surgery, North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand.
Background: Laparoscopic sleeve gastrectomy (LSG) is a potentially refluxogenic operation while Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is regarded as an anti-reflux procedure. The aim of this study is to compare long-term incidence of Barrett's Oesophagus (BO) and gastroesophageal reflux disease (GORD) following LSG and LRYGB.
Methods: Participants of a double-blinded randomized controlled trial comparing banded LRYGB and LSG for remission of type 2 diabetes were contacted to take part.
Investigating the Results of One Anastomosis Gastric Bypass After Primary Metabolic and Bariatric Restrictive Procedures.
Obes Surg
January 2025
Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Hazrat-E Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Previous studies showed a high conversion rate and failure of restrictive procedures, including sleeve gastrectomy (SG), adjustable gastric banding (AGB), gastric plication (GP), and vertical banded gastroplasty (VBG) in a long-term follow-up. The current study aims to evaluate the efficacy and safety of a revisional one anastomosis gastric bypass (OAGB) for weight loss and treatment of obesity-related problems after primary metabolic and bariatric restrictive procedures.
Methods: A retrospective study on prospectively collected data was conducted on a sample of 151 patients who experienced insufficient weight loss or weight regain after primary restrictive surgeries and underwent OAGB as a revisional procedure.
Copper Deficiency: A Frequently Overlooked Complication After MBS-A Systematic Review and Meta-analysis.
Obes Surg
January 2025
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, PR China.
This study reviews the prevalence of copper (Cu) deficiency in patients for metabolic and bariatric surgery (MBS), as well as the long-term outcomes related to the prevalence of Cu deficiency after undergoing MBS. A systematic literature search and meta-analysis were conducted in PubMed, Web of Science, and Scopus for articles published by August 31, 2024. The search terms included metabolic and bariatric surgery, weight loss surgery, metabolic surgery, obesity surgery, sleeve gastrectomy, gastric banding, gastric bypass, duodenal switch, duodenojejunal bypass, copper, copper deficiency, and hypocuposemia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!