Context: Pheochromocytomas are catecholamine-producing tumors that are generally benign but that can also present as or develop into malignancy. Occurrence of malignant pheochromocytomas can only be asserted by imaging of metastatic lesions.
Objectives: We conducted a gene expression profiling of benign and malignant tumors to identify a gene signature that would allow us to discriminate benign from malignant pheochromocytomas and to gain a better understanding of tumorigenic pathways associated with malignancy.
Design: A total of 36 patients with pheochromocytoma was studied retrospectively. There were 18 (nine benign and nine malignant) tumors used for gene expression profiling on pangenomic oligonucleotide microarrays.
Results: We identified and validated a set of predictor genes that could accurately distinguish the two tumor subtypes through unsupervised clustering. Most of the differentially expressed genes were down-regulated in malignant tumors, and several of these genes encoded neuroendocrine factors involved in prominent characteristics of chromaffin cell biology. In particular, the expression of two key processing enzymes of trophic peptides, peptidylglycine alpha-amidating monooxygenase and glutaminyl-peptide cyclotransferase, was reduced in malignant pheochromocytomas.
Conclusion: The gene expression profiling of benign and malignant pheochromocytomas clearly identified a set of genes that could be used as a prognostic multi-marker and revealed that the expression of several genes encoding neuroendocrine proteins was reduced in malignant compared with benign tumors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/jc.2007-1253 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Pediatric Case of Multiple Bilateral Symmetric Eccrine Angiomatous Hamartoma.
Acta Dermatovenerol Croat
November 2024
Prof. Ilke Beyitler, Near East University, Faculty of Medicine, Near East Boulevard, Nicosia, Cyprus;
Eccrine angiomatous hamartoma (EAH) is a rare benign skin neoplasm characterized by an increased size and number of eccrine glands or ducts, along with proliferation of vascular structures in the dermis. This case is unique in its presentation of bilateral symmetrical nodules on both hands and the development of new nodules during puberty. It highlights the need for further research and understanding of this rare condition and its potential progression over time.
View Article and Find Full Text PDFConstruction and evaluation of a multifactorial clinical model for discriminating benign and malignant breast tumors using LASSO algorithm based on retrospective cohort study.
Am J Cancer Res
December 2024
Department of Breast Surgery, Huangpu Branch, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200011, China.
Breast cancer is one of the malignant tumors that seriously threaten women's health, and early diagnosis and detection of breast cancer are crucial for effective treatment. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an important diagnostic tool that allows for the dynamic observation of blood flow characteristics of breast tumors, including small lesions within the affected tissue. Currently, it is widely used in clinical practice and has been shown promising prospects.
View Article and Find Full Text PDFPreliminary study on detection and diagnosis of focal liver lesions based on a deep learning model using multimodal PET/CT images.
Eur J Radiol Open
June 2025
Department of Nuclear medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Objectives: To develop and validate a deep learning model using multimodal PET/CT imaging for detecting and classifying focal liver lesions (FLL).
Methods: This study included 185 patients who underwent F-FDG PET/CT imaging at our institution from March 2022 to February 2023. We analyzed serological data and imaging.
Utility of Retroperitoneal Laparoscopic Surgery for Retroperitoneal Tumors.
JSLS
January 2025
Department of Urology, University of Yamanashi Graduate School of Medical Sciences, Chuo, Yamanashi, Japan. (all authors).
Introduction: Retroperitoneal laparoscopic surgery for benign retroperitoneal tumors is often challenging because of variations in the tumor location and size. In this study, we present a retroperitoneal laparoscopic resection technique used at our institution to treat benign retroperitoneal tumors.
Materials And Methods: This retrospective case series included nine consecutive patients who underwent retroperitoneal laparoscopic tumor resection between 2011 and 2023.
A Rare Case of Bladder Melanosis: A Case Report and Review of the Literature.
Cureus
December 2024
Urology, Rotherham District General Hospital, Rotherham, GBR.
Bladder melanosis is a rare and poorly understood condition involving melanin pigmentation within the urothelial mucosa. Cases often present with haematuria, urinary obstructive symptoms, or cystitis. While generally considered benign, its potential association with malignancy warrants regular monitoring, as cases have previously been reported of an association with urothelial carcinoma and melanoma, although it is unclear whether there is a causal relationship.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!