[A practical guide for the management of gliomas].

Bull Cancer

Centre pluridisciplinaire d'oncologie, Centre hospitalier universitaire vaudois(CHUV), 46, rue du Bugnon, CH-1011 Lausanne, Suisse.

Published: September 2007

The management of gliomas in daily clinical practice is challenging. It requires a multidisciplinary and coordinated approach involving neurosurgery, radiotherapy and, finally, chemotherapy. Important progress has been made during the last years with the introduction of a combined treatment associating standard radiotherapy with concomitant chemotherapy using temozolomide, a novel alkylating agent. For the first time in many years a new treatment strategy translated into a significant prolongation of survival. In parallel, molecular markers (e.g. loss of heterozygosity on chromosomes 1p and 19q or methylation of the methyl-guanine methyl transferase [MGMT] gene promoter) allowed for identification of distinct subtypes of glioma or prediction of treatment response. In this "Practical Guide", we describe the daily practice and aim at answering some common questions in the management of patients suffering from glioblastoma, astrocytoma, oligodendroglioma and low grade glioma. The therapeutic options presented here are based on evidences from the literature. In the absence of documented evidence, the empirical choices from our local practice are explained and justified.

Download full-text PDF

Source

Publication Analysis

Top Keywords

practical guide
4
guide management
4
management gliomas]
4
gliomas] management
4
management gliomas
4
gliomas daily
4
daily clinical
4
clinical practice
4
practice challenging
4
challenging requires
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!