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Evaluation of Five Ready-to-Use Bases for the Topical Administration of Propranolol Hydrochloride to Treat Infantile Hemangioma.
Pharmaceutics
January 2025
Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
: Since 2008, following clinical studies conducted on children that revealed the ability of the β-adrenergic antagonist propranolol to inhibit capillary growth in infantile hemangiomas (IHs), its oral administration has become the first-line treatment for IHs. Although oral propranolol therapy at a dosage of 3 mg/kg/die is effective, it can cause systemic adverse reactions. This therapy is not necessarily applicable to all patients.
View Article and Find Full Text PDFPrediction Model for Flake Line Defects in Metallic Injection Molding: Considering Skin-Core Velocity and Alignment.
Polymers (Basel)
January 2025
Department of Mechanical Engineering, Sogang University, Seoul 04107, Republic of Korea.
Metallic injection molding combines aluminum flake metallic pigments with polymers to directly produce components with metallic luster, improving production efficiency and reducing environmental impact. However, flake line defects that occur in regions where ribs or flow paths intersect remain a significant challenge. This study proposes a velocity model that considers the flow characteristics between the surface and core layers and an alignment model that incorporates the orientation of aluminum flakes to predict appearance defects.
View Article and Find Full Text PDFCharacterization of Esocid Herpesvirus 1 (EsHV1) from Europe.
Pathogens
January 2025
Swedish Veterinary Agency, 751 89 Uppsala, Sweden.
During routine sampling of northern pike, a male with circular blue-metallic granular spots mainly located on the head and back was identified. Histological investigations presented multifocally thickened epidermis rich in basophilic large structures with a granulated rim and a dense, non-granulated center. Other organs showed no signs of infection.
View Article and Find Full Text PDFDepression Recognition Using Daily Wearable-Derived Physiological Data.
Sensors (Basel)
January 2025
Department of Psychological and Cognitive Sciences, Tsinghua University, Beijing 100084, China.
The objective identification of depression using physiological data has emerged as a significant research focus within the field of psychiatry. The advancement of wearable physiological measurement devices has opened new avenues for the identification of individuals with depression in everyday-life contexts. Compared to other objective measurement methods, wearables offer the potential for continuous, unobtrusive monitoring, which can capture subtle physiological changes indicative of depressive states.
View Article and Find Full Text PDFIdentification of Key Predictors of Cryoglobulinemia Severity at Diagnosis: Threshold, Type, and Severity Score at Diagnosis.
J Clin Med
January 2025
Department of Pulmonary Medicine, European Hospital Georges Pompidou, 75015 Paris, France.
: Cryoglobulinemia (CG) syndrome is a heterogeneous condition characterized by the presence of cryoglobulins in serum, often leading to vasculitis with protean clinical manifestations. Understanding the presentation of cryoglobulinemia-related symptoms based on cryoprecipitate levels, GC type, and severity at diagnosis is essential for effective management. Hence, this study aimed to provide a comprehensive analysis of patients with positive cryoglobulin detection to investigate these aspects.
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