AI Article Synopsis
- MSG-induced obesity in rats leads to hyperinsulinemia, insulin resistance, and increased parasympathetic activity.
- Early subdiaphragmatic vagotomy was tested to see if it could prevent the decline in insulin sensitivity in MSG-obese rats.
- Results showed that while vagotomy reduced fat tissue and improved glucose tolerance and insulin sensitivity, it did not prevent overall obesity, indicating a complex relationship between insulin levels and fat accumulation.
Article Abstract
Hypothalamic MSG-obese rats show hyperinsulinemia and tissue insulin resistance, and they display intense parasympathetic activity. Current analysis investigates whether early subdiaphragmatic vagotomy prevents tissue insulin sensitivity impairment in adult obese MSG-rats. Hypothalamic obesity was induced by MSG (4 mg/g BW), daily, from birth up to 5 days. Control animals receiving saline solution. On the 30th day rats underwent bilateral subdiaphragmatic vagotomy or sham surgery. An intravenous glucose tolerance test (i.v.GTT) was performed when rats turned 90 days old. Total white fat tissue (WAT) from rat carcass was extracted and isolated; the interscapular brown fat tissue (IBAT) was weighed. Rather than blocking obesity, vagotomy reduced WAT and IBAT in MSG-obese rats when the latter were compared to sham MSG-rats. High blood fasting insulin and normal glucose levels were also observed in MSG-obese rats. Although glucose intolerance, high insulin secretion, and significant insulin resistance were recorded, vagotomy improved fasting insulinemia, glucose tolerance and insulin tissue sensitivity in MSG-obese rats. Results suggest that increased fat accumulation is caused, at least in part, by high blood insulin concentration, and enhanced parasympathetic activity on MSG-obese rats.
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| http://dx.doi.org/10.1007/s12020-007-0021-z | DOI Listing |
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