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KRT9 is required for GBP5 suppression of human respiratory syncytial virus.
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Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin, China.
Unlabelled: Respiratory syncytial virus (RSV) infections continue to plague infants, young children, and older individuals worldwide. Since there is no specific treatment for RSV, characterizing the interactions between RSV and host factors remains crucial for the eventual development of robust therapeutic interventions. In our previous study, guanylate binding protein 5 (GBP5) was shown to promote excessive RSV-small hydrophobic (RSV-SH) protein secretion by microvesicles and inhibited viral replication.
View Article and Find Full Text PDFExtracellular vesicles in ZIKV infection: Carriers and facilitators of viral pathogenesis?
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Virology Group, Vice-Chancellor of Research, Universidad El Bosque, Bogotá, Colombia.
Zika virus (ZIKV) is a flavivirus of significant epidemiological importance, utilizing various transmission strategies and infecting "immune privileged tissues" during both the pre- and postnatal periods. One such transmission method may involve extracellular vesicles (EVs). EVs can travel long distances without degrading, carrying complex messages that trigger different responses in recipient cells.
View Article and Find Full Text PDFComparing to three other enteric pathogens in OligoMM mice reveals pathogen-specific host and microbiota responses.
Gut Microbes
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Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland.
, non-typhoidal spp., and enteropathogenic/enterohemorrhagic (EPEC/EHEC) are leading causes of food-borne illness worldwide. has been used to model EPEC and EHEC infection in mice.
View Article and Find Full Text PDFAutoantibodies in COVID-19: implications for disease severity and clinical outcomes.
Front Immunol
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Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Few pathogens have historically been subjected to as intense scientific and clinical scrutiny as SARS-CoV-2. The genetic, immunological, and environmental factors influencing disease severity and post-infection clinical outcomes, known as correlates of immunity, remain largely undefined. Clinical outcomes of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to those with life-threatening COVID-19 symptoms.
View Article and Find Full Text PDFidentification of chilli genome encoded MicroRNAs targeting the 16S rRNA and genes of " phytoplasma trifolii.
Front Bioinform
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Department of Biotechnology, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, Uttar Pradesh, India.
Phytoplasma, a potentially hazardous pathogen associated with witches' broom, is an economically harmful disease-producing bacteria that damages chilli cultivation. Phytoplasma-infected plants display various symptoms that indicate significant disruptions in normal plant physiology and behaviour. Diseases caused by phytoplasma are widespread and have a major economic impact on crop quality and yield.
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