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Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury.
Cell Biosci
January 2025
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200438, People's Republic of China.
Background: Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptors. Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) and transient receptor potential vanilloid 1 (TRPV1). However, the role of AEA and these receptors in the hyperactivity of nociceptors after SCI remains unclear.
View Article and Find Full Text PDFPre-assembled nanospheres in mucoadhesive microneedle patch for sustained release of triamcinolone in the treatment of oral submucous fibrosis.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
August 2024
Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University; Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine; Hunan 3D Printing Engineering Research Center of Oral Care; WANG Songling Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha 410078.
Objectives: Drug-loaded mucoadhesive silk fibroin (SF) microneedle patch can overcome the limitations of low bioavailability and significant pain associated with traditional treatment methods, such as topical application or injection of triamcinolone for oral submucous fibrosis (OSF). However, these systems release the drug too quickly, failing to meet the clinical requirements. This study aims to construct a mucoadhesive SF microneedle patch pre-assembled with silk fibroin nanospheres (SFN) and explore its ability to sustain the release of triamcinolone in the treatment of OSF.
View Article and Find Full Text PDFAlopecia Induced by Poly-L-Lactic Acid Injection.
Cutis
November 2024
Drs. Cortez, Hassun, Linhares, Pinheiro, Florenço, Michalany, Bagatin, and Nascimento are from the Federal University of São Paulo, Brazil. Drs. Cortez, Hassun, Linhares, Pinheiro, Florenço, Bagatin, and Nascimento are from the Department of Dermatology, and Dr. Michalany is from the Department of Dermatopathology. Drs. Cortez de Almeida and Melo are from Department of Dermatology, Rio de Janeiro State University, Brazil.
Cosmetic procedures carry inherent risks of adverse events. Though rarely reported, transient and permanent alopecia are potential complications of these procedures. We report the case of a 35-year-old woman who developed pain and patches of nonscarring alopecia with erythema and edema following aesthetic application of poly-L-lactic acid (PLLA) on the face and along the frontal hairline.
View Article and Find Full Text PDFEndometriosis presenting as catamenial pneumothorax, pneumopericardium and pneumoperitoneum.
BMJ Case Rep
January 2025
Pulmonary Medicine, K S Hegde Medical Academy, Mangaluru, Karnataka, India
A nulliparous woman in her late 30s with a history of pericardial patch repair for atrial septal defect and completed treatment for pulmonary tuberculosis 9 years ago presented with chest pain, breathlessness and abdominal pain. Radiological imaging revealed right-sided pneumothorax, pneumopericardium and pneumoperitoneum for which an intercostal drain (ICD) was placed. A contrast-enhanced CT of the abdomen showed a distal stomach perforation, which was managed conservatively.
View Article and Find Full Text PDFCopper Increases the Cooperative Gating of Rat P2X2a Receptor Channels.
Pharmaceuticals (Basel)
November 2024
Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo 1781421, Chile.
P2X receptor channels are widely expressed in the CNS, where they have multiple functions in health and disease. The rat P2X2a (rP2X2a) receptor channel is modulated by copper, an essential trace element that plays important roles in synaptic modulation and neurodegenerative disorders. Although essential extracellular amino acids that coordinate copper have been identified, the exact mechanism of copper-induced modulation has not been yet elucidated.
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