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Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis.
BMJ Open Gastroenterol
January 2025
Inflammatory Bowel Disease Center and Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Objective: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). S1P receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme.
View Article and Find Full Text PDFA carboxymethyl chitosan and dextran hydrogel with slow and rapid photothermal conversion for sequential promoting burn wound healing and inhibiting scar proliferation.
Carbohydr Polym
February 2025
School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, PR China. Electronic address:
Facilitating swift burn wound healing while effectively preventing scar formation continues to be a considerable challenge in medical practice. In this study, an injectable carboxymethyl chitosan/oxidized dextran/polyvinylpyrrolidone/dopamine (COPD) hydrogel was designed for the effective sequentially promotion of burn wound healing and inhibition of scar formation. The COPD hydrogel precursor solution was injected into the burn wound via a double-barreled syringe and transformed into an adherent hydrogel within 25 s.
View Article and Find Full Text PDFAdvancing analytical and graphical methods for binary and ternary mixtures: The toxic interactions of divalent metal ions in human lung cells.
Heliyon
November 2024
Department of Environmental Science, Baylor University, Waco, TX 76798-7266, USA.
Article Synopsis
- Humans are frequently exposed to complex mixtures of environmental chemicals, which can lead to negative health effects; much research has focused on binary mixtures, but the interactions in mixtures of three or more components have not been well studied.
- In this study, researchers explored the toxic interactions among eight divalent metal ions using a human lung model, evaluating eight individual metals and various binary and ternary combinations to quantify their toxicity levels.
- The findings revealed significant variations in toxicity among the metals, with notable synergistic and antagonistic interactions, particularly between cadmium-copper and iron-zinc, utilizing advanced modeling techniques to visualize these complex interactions for the first time in toxicology research.
Bacterial nanocelluloses as sustainable biomaterials for advanced wound healing and dressings.
J Mater Chem B
December 2024
Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer 34396, Istanbul, Türkiye.
Wound healing remains a significant clinical challenge, calling for innovative approaches to expedite the recovery process and improve patient outcomes. Bacterial nanocelluloses (BNCs) have emerged as a promising solution in the field of wound healing and dressings due to their unique properties such as high crystallinity, mechanical strength, high purity, porosity, high water absorption capacity, biodegradability, biocompatibility, sustainability, and flexibility. BNC-based materials can be applied for the treatment of different types of wounds, from second-degree burns to skin tears, biopsy sites, and diabetic and ischemic wounds.
View Article and Find Full Text PDFInfluence of copper ion cross-linked CMC-PVA film on cell viability and cell proliferation study.
Int J Biol Macromol
December 2024
Chemical Engineering Group and Centre for Petroleum Research, CSIR-North East Institute of Science and Technology, Jorhat, Assam 785006, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India. Electronic address:
Article Synopsis
- The study involves creating films using carboxymethyl cellulose and polyvinyl alcohol, with citric acid as a cross-linking agent and glycerol as a plasticizer.
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- The findings suggest these films could potentially be used for treating second-degree burn wounds, highlighting their effectiveness, cell attachment, and water vapor permeability.
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