Cardiovascular manifestations of hypereosinophilic syndromes.

Immunol Allergy Clin North Am

Allergy and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room B1-05, Bldg. 4, Bethesda, MD 20892, USA.

Published: August 2007

The hypereosinophilic syndromes (HESs) are characterized by persistent marked eosinophilia (>1500 eosinophils/mm(3)), the absence of a primary cause of eosinophilia (such as parasitic or allergic disease), and evidence of eosinophil-mediated end organ damage. Cardiovascular complications of HES are a major source of morbidity and mortality in these disorders. The most characteristic cardiovascular abnormality in HES is endomyocardial fibrosis. Patients who have an HES also may develop thrombosis, particularly in the cardiac ventricles, but also occasionally in deep veins. Because of the rarity of these disorders, specific guidelines for the management of the cardiac and thrombotic complications of HES are lacking. This article reviews the diagnosis and management of the cardiovascular manifestations of HES.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048688PMC
http://dx.doi.org/10.1016/j.iac.2007.07.001DOI Listing

Publication Analysis

Top Keywords

cardiovascular manifestations
8
hypereosinophilic syndromes
8
cardiovascular
4
manifestations hypereosinophilic
4
syndromes hypereosinophilic
4
syndromes hess
4
hess characterized
4
characterized persistent
4
persistent marked
4
marked eosinophilia
4

Similar Publications

Subvalvular aortic stenosis typically manifests at a young age and rarely presents in adulthood. It may cause left ventricular outflow tract stenosis, which requires surgical treatment in severe cases. The coexistence of discrete subvalvular aortic stenosis and quadricuspid aortic valve is a highly unusual finding.

View Article and Find Full Text PDF

Berardinelli-Seip congenital lipodystrophy (BSCL), also known as congenital generalized lipodystrophy (CGL), is an exceptionally rare autosomal recessive disorder marked by a significant deficiency of adipose tissue throughout the body. This lack of adipose tissue, normally found beneath the skin and between internal organs, leads to impaired adipocyte formation and fat storage, causing lipids to accumulate in atypical tissues such as muscles and the liver. The extent of adipose tissue loss directly influences the severity of symptoms, which can include a muscular appearance, increased appetite, bone cysts, marrow fat depletion, acromegalic features, severe insulin resistance, skeletal muscle hypertrophy, hypertrophic cardiomyopathy, hepatic steatosis, hepatomegaly, cirrhosis, and intellectual disability.

View Article and Find Full Text PDF

Hypothyroidism is typically associated with bradyarrhythmias, but can rarely precipitate life-threatening ventricular arrhythmias. We present a case of severe hypothyroidism manifesting as polymorphic ventricular tachycardia (VT). A previously healthy woman in her early 50s presented with an acute onset of breathlessness and on examination had hypotension and tachycardia.

View Article and Find Full Text PDF

Background: Andersen-Tawil syndrome (ATS) is a rare autosomal dominant disorder caused by variants in the gene. It is associated with periodic paralysis, dysmorphic features and cardiac arrhythmias. The syndrome exhibits incomplete penetrance, leading to a broad spectrum of clinical manifestations, making diagnosis challenging.

View Article and Find Full Text PDF

Torsion of Extralobar Pulmonary Sequestration Presenting as Posterior Mediastinal Mass.

Ann Thorac Surg Short Rep

December 2024

Department of Thoracic and Cardiovascular Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea.

Torsion of extralobar pulmonary sequestration is a rare congenital anomalous condition that can manifest with various symptoms, including abdominal pain. However, a masslike lesion in the mediastinum can be easily overlooked when the clinician focuses only on abdominal pain. By using magnetic resonance imaging, a few features specific to the torsion of extralobar pulmonary sequestration can be identified, and that information will be helpful.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!