AI Article Synopsis
- The Drosophila PCP gene prickle is known to influence gastrulation in early embryos, but its role in brain development is unclear.
- Research shows that mouse Prickle1 and Prickle2 are consistently expressed in the brain during embryonic stages, especially in mature neurons.
- Depleting Prickle1 or Prickle2 reduces neurite outgrowth in Neuro2a cells, suggesting these genes may promote neurite formation during brain development.
Article Abstract
The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development.
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| http://dx.doi.org/10.1016/j.febslet.2007.08.075 | DOI Listing |
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