AI Article Synopsis
- Nail hardeners were introduced in the 1960s as formaldehyde solutions, but adverse effects were reported shortly after, in 1966.
- Common reactions to nail hardeners included onycholysis, chromonychia, subungual hemorrhage, and hyperkeratosis.
- Onycholysis can be either non-inflammatory or inflammatory, often causing pain and may lead to further issues such as paronychia and dermatitis.
Article Abstract
Nail hardeners appeared in the market during the 1960s. They were basically solutions of formaldehyde. The first adverse effects were published in 1966 (1). Reactions were onycholysis, chromonychia, subungual haemorrhage, and hyperkeratosis. Onycholysis may be non-inflammatory or inflammatory, and is accompanied by throbbing pain. Inflammatory reactions are followed by paronychia and occasional dermatitis on the digital pulpa.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0536.2007.01121.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nail changes in patients receiving systemic isotretinoin therapy.
Sci Rep
October 2024
Dermatology and Venereology, Ankara Training and Research Hospital, Health Sciences University, Hacettepe Mh. Ulucanlar Cd. No: 89, Altındağ/Ankara, Turkey.
Article Synopsis
- - The study investigated nail changes caused by isotretinoin treatment in 200 patients with acne vulgaris, comparing 100 on isotretinoin and 100 on topical treatments.
- - Results showed that 34% of patients on isotretinoin experienced nail changes, with onychoschizia being the most common, while only 11% in the topical group had similar issues.
- - Nail changes associated with isotretinoin are linked to the total dose taken, not the duration of treatment, but these changes are completely reversible after stopping the medication.
Nail Changes Following Valproate Therapy.
Kathmandu Univ Med J (KUMJ)
September 2024
Department of Dermatology, Pokhara Academy of Health Sciences, Pokhara, Nepal.
Article Synopsis
- Valproic acid is commonly used to treat seizure disorders, mood disorders, and migraines.
- Changes in nails, such as onycholysis and discoloration, are rare side effects of sodium valproate.
- These nail changes occur regardless of patient age, dose, or treatment duration, but they can reverse after stopping the medication.
The spectrum of cutaneous toxicities related to novel genitourinary cancer therapies.
Crit Rev Oncol Hematol
August 2024
Vita-Salute San Raffaele University, Milan, Italy; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.
Article Synopsis
- - Genitourinary cancers (GUCs) such as renal cell carcinoma, urothelial carcinoma, and prostate cancer have rapidly evolving treatments that can lead to significant skin-related side effects, referred to as cutaneous adverse events (AEs).
- - A literature review analyzed various therapies, including immune checkpoint inhibitors and antiangiogenic drugs, finding common AEs like rashes and itching, with unique skin reactions linked to specific treatments.
- - Recognizing and managing these dermatologic AEs is crucial, as they can affect patients' quality of life and treatment adherence, emphasizing the need for teamwork among healthcare providers in monitoring and addressing these skin issues.
[Cutaneous adverse events to systemic anticancer therapies : Hand-foot syndrome and nail changes].
Dermatologie (Heidelb)
June 2024
Universitäts-Klinik für Dermatologie, Venerologie, Allergologie und Phlebologie, Johannes Wesling Klinikum Minden, Minden, Deutschland, 32427.
Article Synopsis
- Hand-foot syndrome (HFS) and nail changes are common side effects of cancer treatments, with two main types identified: chemotherapy-associated and kinase-inhibitor-associated HFS.* -
- The first type involves painful skin reactions due to sweat gland toxicity, while the second leads to callus-like thickening from mechanical pressure, with management strategies including avoiding stress, using topical treatments, and cooling during infusions.* -
- The review highlights the effects on various parts of the nail during treatment and provides guidance on preventing and managing HFS and nail disorders in cancer patients.*
Nail changes are a common side effect of taxane chemotherapy, although onycholysis is quite a rare complication the correct management of which is poorly standardized. These case reports provide a description and analysis of onycholysis, a rare but noteworthy complication observed during taxane-based chemotherapy with concomitant cryotherapy in two patients with breast cancer. Despite prophylactic measures, both cases experienced nail complications during Paclitaxel treatment, underlining the complex nature of onycholysis during taxane therapy and highlighting the critical role of nail assessment and infection screening.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!