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J Wildl Dis
January 2025
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Ave., St. Paul, Minnesota 55108, USA.
Effects on physiology were evaluated in 49 free-ranging moose (Alces alces), 11 adult males, 36 females, two of unknown sex) in Minnesota, USA, immobilized by helicopter darting with thiafentanil (10 mg) and xylazine (30 mg) in February 2020 and March 2021. Pursuit time (PT), induction time (IT), recumbency time (RT), recovery time (RC), temperature (T), and body position were recorded. For 14 females, respiratory rate (RR), pulse rate (PR), and pulse oximetry (SpO2) were obtained before and at 1, 5, and 10 min after 4 L/min nasal oxygen supplementation was started; pH, lactate (Lac), arterial oxygen (PaO2), and carbon dioxide (PaCO2) tensions were obtained pre-treatment and 5 min post-treatment.
View Article and Find Full Text PDFJ Zoo Wildl Med
March 2024
Department of Clinical Sciences Colorado State University, Fort Collins, CO 80523, USA.
A mixture of butorphanol, azaperone, and medetomidine (BAM) is frequently used for immobilization of North American hoofstock. Common adverse effects include respiratory depression, hypoxemia, and bradycardia. In this nonblinded crossover study the efficacy of two a-2 adrenergic antagonists, tolazoline and vatinoxan, were evaluated in alleviating adverse effects of BAM in Rocky Mountain elk ().
View Article and Find Full Text PDFActa Paediatr
February 2022
Discipline of Paediatrics, Trinity College, the University of Dublin, Dublin, Ireland.
Aim: Pulmonary haemorrhage (PH) is an acute catastrophic event with low incidence yet high mortality among neonates. We aimed to systematically review the management of PH.
Methods: A search was carried out of the PubMed, EMBASE and Cochrane databases according to the PRISMA guidelines.
Objective: To evaluate and compare the anesthetic, analgesic, and cardiorespiratory effects of tiletamine-zolazepam-detomidine-butorphanol (TZDB), tiletamine-zolazepam-xylazine-butorphanol (TZXB), and ketamine-detomidine-butorphanol (KDB) in pigs and to assess anesthetic recovery duration and quality following administration of tolazoline as a reversal agent.
Animals: 11 healthy 2.5-month-old castrated male Landrace mixed-breed pigs.
J Pharm Biomed Anal
October 2019
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong. Electronic address:
Dexmedetomidine (DMTD), an α-adrenoceptor agonist, is commonly used for sedation and analgesia in intensive care unit (ICU) patients. The primary plasma metabolites of DMTD are its direct N-glucuronides, namely N-glucuronide of dexmedetomidine (DG1) and N-glucuronide of dexmedetomidine (DG2), accounting for 41% of DMTD metabolism in healthy volunteers. Since variations on the extent of N-glucuronidation could be one of the key factors contributing to the high interpatient differences of DMTD pharmacokinetics in ICU patients and its subsequent sedative effect.
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