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Indoxyl Sulfate Induces Ventricular Arrhythmias Attenuated by Secretoneurin in Right Ventricular Outflow Tract Cardiomyocytes.
Cardiovasc Toxicol
January 2025
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan.
Ventricular arrhythmias (VAs) are major causes of sudden cardiac death in chronic kidney disease (CKD) patients. Indoxyl sulfate (IS) is one common uremic toxin found in CKD patients. This study investigated whether IS could induce VAs via increasing right ventricular outflow tract (RVOT) arrhythmogenesis.
View Article and Find Full Text PDFMitochondrial Calcium Homeostasis and Atrial Fibrillation: Mechanisms and Therapeutic Strategies Review.
Curr Probl Cardiol
January 2025
Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China. Electronic address:
Atrial fibrillation (AF) is tightly linked to mitochondrial dysfunction, calcium (Ca²⁺) imbalance, and oxidative stress. Mitochondrial Ca²⁺ is essential for regulating metabolic enzymes, maintaining the tricarboxylic acid (TCA) cycle, supporting the electron transport chain (ETC), and producing ATP. Additionally, Ca²⁺ modulates oxidative balance by regulating antioxidant enzymes and reactive oxygen species (ROS) clearance.
View Article and Find Full Text PDFMarine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India.
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients' quality of life. Current treatments often provide inconsistent relief and notable adverse effects, highlighting the urgent need for safer and more effective alternatives. This review investigates marine-derived bioactive compounds as potential novel therapies for neuropathic pain management.
View Article and Find Full Text PDFThe inhibition of SLC8A1 promotes Ca-dependent cell death in Gastric Cancer.
Biomed Pharmacother
January 2025
Department of Biology, University of Naples Federico II, Naples, Italy; Biogem, Istituto di Biologia e Genetica Molecolare, Ariano Irpino, AV, Italy.
Intracellular Ca homeostasis dysregulation, through the modulation of calcium permeable ion channels and transporters, is gaining attention in cancer research as an apoptosis evasion mechanism. Recently, we highlighted a prognostic role for several calcium permeable channels. Among them, here, we focused on the plasma membrane bidirectional Na/Ca exchanger SLC8A1.
View Article and Find Full Text PDFImportance of Zinc Homeostasis for Normal Cardiac Rhythm.
Curr Cardiol Rev
September 2024
Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Current arrhythmia treatments like ion channel blockers and defibrillators have drawbacks, prompting the need for new strategies to manage heart rhythm issues.
- A promising approach involves monitoring and adjusting specific ion levels, particularly zinc, to prevent or treat arrhythmias due to its significant impact on heart electrical activity.
- Zinc plays a crucial role by interacting with various ion channels and receptors, influencing oxidative stress, inflammation, and even circadian rhythms, highlighting the necessity of maintaining proper zinc levels in the body for heart health.
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