AI Article Synopsis
- PANDAS refers to a condition in children where obsessive-compulsive symptoms and tics arise due to an autoimmune response linked to group A strep infections.
- The condition is thought to affect the basal ganglia in the brain, leading to neuropsychiatric problems.
- Treatment options like plasmapheresis are being explored for their effectiveness in adult patients with OCD and tic disorders triggered by these infections.
Article Abstract
The acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) has been assigned to a subgroup of patients experiencing pediatric onset obsessive-compulsive symptoms and tics as a result of autoimmune response to group A beta-hemolytic streptococcal infection. It has been hypothesized that an immune process initiated by infection affects the basal ganglia and causes neuropsychiatric symptoms. In cases with severe neuropsychiatric symptoms, the use of treatment strategies that interrupt the autoimmune process responsible for the pathogenesis of PANDAS, such as therapeutic plasmapheresis or intravenous immunoglobulin, has been proposed. In this paper, we discuss the effect of plasmapheresis treatment in 4 adult cases of obsessive-compulsive disorder and tic disorder triggered by streptococcal infections.
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