AI Article Synopsis
- Deficiencies in the complement protein C4, particularly in its C4A and C4B isotypes, are linked to autoimmune diseases and infections, which may also relate to schizophrenia.
- Previous studies hinted at abnormalities in C4B in individuals with schizophrenia and other mental health conditions.
- In this study involving Armenian patients, while the presence of a specific C4 variant (C4BQ0) was similar between schizophrenic patients and healthy controls, the serum C4B protein levels were significantly lower in those with schizophrenia.
Article Abstract
Partial and/or complete deficiency of the complement protein C4 is associated with autoimmune and infectious diseases. Infectious or autoimmune processes may have a role in schizophrenia. Previous reports suggest abnormalities in the complement C4B isotype in schizophrenia and other mental disorders. We assessed C4A and C4B isotypes and serum C4B protein concentration in Armenian schizophrenic patients. Although there was no difference in frequency of C4BQ0, C4B serum protein level was significantly decreased in the schizophrenic patients compared with healthy controls.
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| http://dx.doi.org/10.1080/15622970701227803 | DOI Listing |
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