Objective: Circulating leptin levels positively correlate with adult BMI and size at birth. Previous studies found gender-specific associations between polymorphisms in the leptin gene and postnatal obesity-related traits or circulating leptin levels. We examined the relationships among leptin gene polymorphisms, size for gestational age, umbilical cord leptin, and gender.
Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the leptin gene in 261 newborns (72 low birth weight Caucasians, 189 randomly-selected African-Americans). In African-Americans, umbilical cord leptin and free testosterone levels were measured. Linear regression was used to identify significant predictors of size for gestational age or cord leptin levels and gender x genotype interaction effects.
Results: There is a significant interaction between gender and genotype at site -2548 (A/G). Among low birth weight Caucasians, the A allele was associated with an increase in female size for gestational age, while the A allele was associated with decreased male birth size. Among African-Americans, the A allele was associated with a decrease in umbilical cord leptin in females and with an increase in cord leptin in males. Cord testosterone levels were not a significant predictor of cord leptin levels either among all African-American newborns or among strata of -2548 genotypes and gender.
Conclusion: In male and female fetuses, site -2548 of the leptin gene may differently affect the expression level of the leptin gene or the rate of fetal growth. This gender-specific effect does not appear to be mediated by the level of free testosterone at delivery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/17477160701286734 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations between prenatal exposure to PFAS and cardiometabolic health in preadolescents.
Environ Res
December 2024
Institut de recherche en santé, environnement et travail (Irset), Univ Rennes, Inserm, EHESP, 9 Av. Professeur Léon Bernard, Rennes, France. Electronic address:
Introduction: While a number of studies have examined the effects of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on childhood obesity, the results reported have been inconsistent and few studies have integrated biological markers. The aim of this study was to investigate the associations between prenatal exposure to PFAS and cardiometabolic health parameters at age 12, taking pubertal stage into consideration.
Method: This study included 394 mother-child pairs enrolled in the PELAGIE mother-child cohort (France).
Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study.
Clin Epigenetics
November 2024
Department of Epidemiology, School of Public Health, Brown University, 121 South Main Street, Providence, RI, 02903, USA.
Background: Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, has been associated with adiposity in children, but its association with other cardiometabolic risk markers remains understudied. We employed data from the Health Outcomes and Measures of the Environment (HOME) study, a prospective pregnancy and birth cohort in the greater Cincinnati metropolitan area, to examine whether accelerated epigenetic age at birth as well as accelerated epigenetic age and faster pace of biological aging at age 12 years were associated with higher cardiometabolic risk in adolescents.
View Article and Find Full Text PDFEffects of Mediterranean diet during pregnancy on the onset of overweight or obesity in the offspring: a randomized trial.
Int J Obes (Lond)
January 2025
Department of Translational Medical Science, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Article Synopsis
- The PREMEDI study investigated how nutritional counseling promoting the Mediterranean Diet (MD) during pregnancy affects the risk of overweight or obesity in children at 24 months.
- In this trial, 104 women were divided into two groups: one received standard care while the other also received MD-focused nutritional counseling.
- Results showed that children of mothers who adhered to the MD were significantly less likely to be overweight or obese at 24 months, indicating that the diet may lead to epigenetic changes that influence weight regulation.
The association between macrosomia and glucose, lipids and hormones levels in maternal and cord serum: a case-control study.
BMC Pregnancy Childbirth
September 2024
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Background: The formation of macrosomia is associated with excessive nutrition and/or unable to regulate effectively. This case-control study aims to explore the relationship between macrosomia and glucose, lipids and hormones levels in maternal and cord serum.
Methods: In the case-control study, 78 pairs of mothers and newborns were recruited who received care at one hospital of Hebei, China between 2016 and 2019.
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis.
J Neurol Neurosurg Psychiatry
August 2024
Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
Background: Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via multiple mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests of daily and intermittent CR (iCR) in people with MS (pwMS) showed improvements in fatigue and well-being measures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!