AI Article Synopsis
- The study investigated the I/D polymorphism of the ACE gene in breast cancer patients to understand its distribution and how it relates to their health outcomes and features.
- Out of 57 breast cancer patients, the most common genotype was DD (54.4%), while healthy controls also showed a high prevalence of DD (63.5%), but the ID genotype was more frequent in cancer patients (p = .03).
- The DD genotype was linked to negative hormone receptor status, larger tumor size, and lymph node involvement, indicating it may correlate with worse prognosis in breast cancer patients.
Article Abstract
The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DD, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients (p = .03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status (p = .003), tumor size (p = .054), and lymph node involvement (p = .07) but not histologic high grade and c-erb B2 overexpression. These results suggest that the DD genotype may accompany poor prognostic factors and influence the tumor course.
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| http://dx.doi.org/10.2310/6650.2007.00006 | DOI Listing |
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