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Enhancement of photoactivity and cellular uptake of (BuN)[MoI(CHCOO)] complex by loading on porous MCM-41 support. Photodynamic studies as an anticancer agent.
Biomater Adv
September 2022
Departamento de Química Inórganica y Orgánica, Universitat Jaume I, Av. Sos Baynat s/n, 12071 Castellón, Spain. Electronic address:
Article Synopsis
- The study developed a new molybdenum-based hybrid photosensitizer (1@MCM-41) by incorporating a hexanuclear molybdenum cluster into amino-decorated mesoporous silica nanoparticles (MCM-41), which is known for its high porosity and surface area.
- The hybrid photosensitizer effectively generates singlet oxygen for photodynamic therapy, showing significant activity against human cervical cancer (HeLa) cells, reducing their viability by up to 70% after 20 minutes of LED light exposure.
- The main conclusion highlights that incorporating molybdenum complexes into porous MCM-41 enhances their photoactivity and improves cellular uptake compared to using free clusters.
Structure impact on photodynamic therapy and cellular contrasting functions of colloids constructed from dimeric Au(I) complex and hexamolybdenum clusters.
Mater Sci Eng C Mater Biol Appl
September 2021
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088 Kazan, Russian Federation.
Electrostatically driven self-assembly of [AuL] (L is cyclic PNNP ligand) with [{MoI}(L')] (L' = I, CHCOO) in aqueous solutions is introduced as facile route for combination of therapeutic and cellular contrasting functions within heterometallic colloids (Mo-Au). The nature of L' affects the size and aggregation behavior of crystalline Mo-Au aggregates, which in turn affect the luminescence of the cluster units incorporated into Mo-Au colloids. The spin trap facilitated electron spin resonance spectroscopy technique indicates that the level of ROS generated by Mo-Au colloids is also affected by their size.
View Article and Find Full Text PDFInterfacial uploading of luminescent hexamolybdenum cluster units onto amino-decorated silica nanoparticles as new design of nanomaterial for cellular imaging and photodynamic therapy.
J Colloid Interface Sci
March 2019
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia.
The present work introduces a facile synthetic route to embed phosphorescent K[{MoI}I] and (nBuN)[{MoI}(CHCOO)] clusters (C) onto silica-water interface of amino-decorated silica nanoparticles (SNs, 60 ± 6 nm). The assembled C-SNs gain in the luminescence intensity, which remains stable within three months after their assembly. High uptake capacity of the clusters (8700 of K[{MoI}I] and 6500 of (nBuN)[{MoI}(CHCOO)] per the each nanoparticle) derives from ionic self-assembly and coordination bonds between the cluster complexes and ionic (amino- and siloxy-) groups at the silica surface.
View Article and Find Full Text PDFAssembly of hexamolybdenum metallic clusters on silicon surfaces.
Chemphyschem
October 2007
Physique des Atomes, Lasers, Molécules et Surfaces PALMS, UMR 6627 CNRS/Université de Rennes 1, 35042 Rennes, France.
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