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Human Dermal Microvascular Arterial and Venous Blood Endothelial Cells and Their Use in Bioengineered Dermo-Epidermal Skin Substitutes.
Small Methods
January 2025
Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Lenggstrasse 30, Zurich, 8008, Switzerland.
The bioengineering of vascular networks is pivotal to create complex tissues and organs for regenerative medicine applications. However, bioengineered tissues comprising an arterial and venous plexus alongside a lymphatic capillary network have not been explored yet. Here, scRNA-seq is first employed to investigate the arterio-venous endothelial cell marker patterning in human fetal and juvenile skin.
View Article and Find Full Text PDFA simple algorithm to derive virtual non-contrast electron density from dual-energy computed tomography data for radiotherapy treatment planning.
Med Phys
January 2025
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Background: The use of iodinated contrast-enhancing agents in computed tomography (CT) improves the visualization of relevant structures for radiotherapy treatment planning (RTP). However, it can lead to dose calculation errors by incorrectly converting a CT number to electron density.
Purpose: This study aimed to propose an algorithm for deriving virtual non-contrast (VNC) electron density from dual-energy CT (DECT) data.
An Evaluation of the Safety of Intravenous Injections of the Natural Extracellular Hemoglobin M101 in Dogs and Monkeys.
Int J Mol Sci
January 2025
HEMARINA S.A., Aéropôle Centre, 29400 Morlaix, France.
Hemoglobin-based oxygen carriers have been developed to compensate the needs of blood for transfusions. Most of them were based on intracellular hemoglobin extracted from bovine or human blood, but unfortunately, this type of hemoglobin did not pass through the last steps of clinical trials. In this context, HEMARINA discovered a natural extracellular hemoglobin, possessing several advantages avoiding intracellular hemoglobin-related side effects.
View Article and Find Full Text PDF[Simultaneous determination of 51 indazole-type synthetic cannabinoids in urine and blood by online solid-phase extraction-liquid chromatography-linear ion trap mass spectrometry].
Se Pu
February 2025
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
To evade legal controls, new psychoactive substances (NPS), which have been designed as substitutes for traditional and synthetic drugs, are gradually dominating the drug market. Synthetic cannabinoids (SCs), which account for the majority of NPS, are rapidly being derivatized; consequently, controlling increasing abuse by merely listing individual compounds is difficult. Therefore, China has included the entire SC category of SCs listed as legal controlled substances since July 1, 2021.
View Article and Find Full Text PDFCarbon-doped bimetallic oxide nanoflakes for simultaneous electrochemical analysis of ascorbic acid, uric acid, and acetaminophen in sweat.
Anal Methods
January 2025
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
Non-invasive continuous detection using tears or sweat as substitutes for blood samples has become an emerging method for real-time monitoring of human health. However, its development is limited by the low sample volume and low level of analytes. The simultaneous determination of multi-analytes with highly sensitive electrochemical sensing platforms has undoubtedly resulted in breakthrough innovations.
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