Unlabelled: Although chronic hepatitis C (CH-C) has consistently been shown to impair patients' health-related quality of life (HRQL), the impact of chronic hepatitis B (CH-B) on HRQL has not been fully explored.
Aim: Compare HRQL between patients with CH-B, CH-C, primary biliary cirrhosis (PBC) and healthy controls.
Design: Three HRQL questionnaires [Chronic Liver Disease Questionnaire (CLDQ), Short Form 36 (SF-36) and the Health Utility Index (HUI Mark-2 and Mark-3)] were administered prospectively. Additional clinical and laboratory data and normative data for healthy individuals, were available.
Analysis: Scores were compared using analysis of variance and multiple regression.
Results: One hundred and forty-six patients with CH-B, CH-C and PBC were included [mean age 47.1 years (+/-11.6), 41% female, 33% cirrhosis]. CH-C and PBC patients scored the lowest on all CLDQ, SF-36 and HUI domains compared with CH-B patients and healthy controls. CH-B patients had scores similar to the healthy population, measured by most CLDQ and SF-36 scales. However, the HUI scores for CH-B patients showed more impairment than population norms. Having CH-B and not having cirrhosis were predictive of utility and HRQL scores in multivariate models.
Conclusions: CH-B patients have better HRQL than CH-C, PBC and population norms. CH-B patients' overall utility scores are lower than population norms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1478-3231.2007.01558.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of cranial growth patterns using craniometric parameters and best-fit logarithmic growth curves.
J Craniomaxillofac Surg
January 2024
Division of Pediatric Plastic Surgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Article Synopsis
- This study provides a comprehensive analysis of cranial growth patterns in a large sample of 1009 Korean children and adolescents, focusing on age- and sex-specific measurements.
- Using thin-slice CT scans, researchers established key cranial parameters and created logarithmic curves for intracranial volume and other measurements, demonstrating that males generally have larger cranial dimensions than females.
- The findings indicate that cranial measurements rapidly increase in the first few years of life and establish reference data that can aid in treating conditions like craniosynostosis in pediatric patients.
The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases.
Diabetol Metab Syndr
May 2023
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, AlBeheira, Egypt.
Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans has different physiological functions including inhibiting the release of insulin and glucagon. Type 2 diabetes mellitus (T2DM) is an endocrine disorder due to relative insulin insufficiency and insulin resistance (IR) is associated with increased circulating hIAPP. Remarkably, hIAPP has structural similarity with amyloid beta (Aβ) and can engage in the pathogenesis of T2DM and Alzheimer's disease (AD).
View Article and Find Full Text PDFPatients' satisfaction on primary healthcare services in China and its associated factors during COVID-19 pandemic: A cross-sectional study.
Malays Fam Physician
January 2023
MD (UNIMAS), M.Med (Family Medicine) Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia.
Introduction: The provision of a satisfactory service by community healthcare centres in China plays an important role in the prevention and control of communicable diseases, especially during the COVID-19 pandemic. However, there is a lack of study in this field. This study aimed to determine the level of patient satisfaction with primary healthcare services in China and its associated factors during the COVID-19 pandemic.
View Article and Find Full Text PDFLiver transplantation recovers hepatic N-glycosylation with persistent IgG glycosylation abnormalities: Three-year follow-up in a patient with phosphomannomutase-2-congenital disorder of glycosylation.
Mol Genet Metab
April 2023
Department of Clinical Genomics, Mayo Clinic, Rochester, MN, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:
Article Synopsis
- PMM2-CDG is the most common congenital disorder of glycosylation, showing a wide range of symptoms from mild neurological issues to severe organ dysfunction, with liver problems being prevalent.
- There are no current cures for PMM2-CDG, but research into new treatments is ongoing, with a notable case of a 4-year-old successfully undergoing liver transplantation.
- Post-transplant, the patient showed significant improvement in growth and liver function, but continued to experience some immune system issues, highlighting the potential benefits and risks of liver transplants for PMM2-CDG patients with severe liver disease.
A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects.
Inflammopharmacology
April 2023
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, AlBeheira, Damanhour, 22511, Egypt.
Parkinson's disease (PD) is an advanced neurodegenerative disease (NDD) caused by the degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age-related disorder, the majority of PD patients are associated with musculoskeletal disorders with prolonged use of analgesic and anti-inflammatory agents, such as non-steroidal anti-inflammatory drugs (NSAIDs). Therefore, NSAIDs can affect PD neuropathology in different ways.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!