Problem: The purpose of the present prospective multi-center study is to investigate the relationship between laparoscopic diagnosis of endometriosis and results of a serum antiendometrial antibody (AEA) assay.
Method Of Study: Indirect immunofluorescence detection of AEA was performed on serum specimens from patients presenting with dysmenorrhea or chronic pelvic pain and infertility (n = 2609) utilizing frozen sections of endometrium acquired on cycle days 18-21 from normally cycling women without endometriosis. Diagnostic laparoscopy was performed within 1 year of AEA assay on 527 tested women.
Results: The relationship between the serum AEA and laparoscopic verification was characterized by a positive predictive value = 88%, negative predictive value = 86%, sensitivity = 87% and specificity = 87%.
Conclusion: The AEA assay is a very good screening test for patients suspected of having endometriosis and should be utilized prior to laparoscopy in diagnostic categories of dysmenorrhea or chronic pelvic pain and infertility.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0897.2007.00523.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Resveratrol activates MAPK/ERK pathway to regulate oestrogen metabolism in type I endometrial cancer.
BMC Complement Med Ther
June 2024
Department of Obstetrics and Gynecology, Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Objective: Endometrial cancer (EC) is an oestrogen-dependent tumour, the occurrence of which is closely related to an imbalance of oestrogen homeostasis. Our previous studies explored the effects of Resveratrol(Res) on oestrogen metabolism. However, systematic research on the exact mechanism of action of Res is still lacking.
View Article and Find Full Text PDFPredictive value of serum anti-endometrium antibody level in infertile patients with polycystic ovary syndrome.
Ir J Med Sci
October 2023
Department of Gynecology, Huanggang Central Hospital of Yangtze University (Dabie Mountain Regional Medical Center), No.126 Qi'an Avenue, Huangzhou District, Huanggang, Hubei, 438000, People's Republic of China.
Background: Polycystic ovary syndrome is the most extensive type of reproductive endocrine disease in department of gynecology.
Aims: This observation aimed to investigate the predictive value of anti-endometrial antibody (EMAb) level in polycystic ovary syndrome (PCOS) complicated with infertility.
Methods: A total of 87 PCOS patients with infertility were selected as the research objects, and 86 healthy women who underwent pre-pregnancy physical examination were volunteers of the control group.
[Mechanism of Fuke Qianjin Capsules in treating intrauterine adhesion in rats through TGF-β1-PI3K/Akt signaling pathway].
Zhongguo Zhong Yao Za Zhi
October 2020
School of Pharmaceutical Science, Hunan University of Chinese Medicine Changsha 410208, China.
To explore the effect of Fuke Qianjin Capsules on anti-endometrial fibrosis in intrauterine adhesion(IUA) rats through TGF-β1-PI3 K/Akt signaling pathway. With female SD rats as the object, IUA rat models were established through mechanical injury and infection, and they were randomly divided into normal group, sham operation group, Bujiale group(0.63 mg·kg~(-1)·d~(-1)), and high-dose Fuke Qianjin Capsules group(1.
View Article and Find Full Text PDFBlood biomarkers for the non-invasive diagnosis of endometriosis.
Cochrane Database Syst Rev
May 2016
Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Level 6, Medical School North,, Frome Rd, Adelaide, SA, Australia, 5005.
Background: About 10% of reproductive-aged women suffer from endometriosis, a costly chronic disease causing pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but is expensive and carries surgical risks. Currently, there are no non-invasive or minimally invasive tests available in clinical practice to accurately diagnose endometriosis.
View Article and Find Full Text PDFInvestigation of diagnostic potentials of nine different biomarkers in endometriosis.
Eur J Obstet Gynecol Reprod Biol
July 2014
Department of Medical Microbiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Objective: To investigate the diagnostic potentials of the serum levels of nine different biomarkers in endometriosis.
Study Design: In this case-controlled, prospective clinical study, 80 women underwent laparoscopy or laparotomy with a preliminary diagnosis of chronic pelvic pain, severe secondary dysmenorrhea, infertility, pelvic endometriosis or pelvic mass. The 60 women with confirmed pelvic endometriosis constituted the endometriosis group, and the other 20 women without endometriosis constituted the control group.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!