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Fine-Tuning Genetic Circuits via Host Context and RBS Modulation.
ACS Synth Biol
January 2025
Faculty of Biosciences, Fisheries and Economics, UiT─The Arctic University of Norway, 9019 Tromsø, Norway.
The choice of organism to host a genetic circuit, the chassis, is often defaulted to model organisms due to their amenability. The chassis-design space has therefore remained underexplored as an engineering variable. In this work, we explored the design space of a genetic toggle switch through variations in nine ribosome binding site compositions and three host contexts, creating 27 circuit variants.
View Article and Find Full Text PDFCirculating Tumor DNA: A New Research Frontier in Urological Oncology from Localized to Metastatic Disease.
Eur Urol Oncol
December 2024
Unit of Medical Oncology and Biomolecular Therapy and CREATE Center for Research and Innovation Medicine, Department of Medical and Surgical Sciences, University of Foggia, Policlinico Riuniti, Foggia, Italy. Electronic address:
Article Synopsis
- Circulating tumor DNA (ctDNA) testing is highlighted as a valuable tool for prognosis and treatment guidance in urological tumors, providing insights into disease progression and drug resistance.
- A literature review showed that ctDNA levels increase from localized to metastatic disease in prostate and urothelial cancers, suggesting its potential in risk stratification and treatment choices.
- Although ctDNA analysis has promising implications for clinical management, further research, particularly in renal cell carcinoma, is needed to fully integrate it into routine practice through a collaborative approach among various specialists.
Automatic identification of clinically important species by artificial intelligence-based image recognition: proof-of-concept study.
Emerg Microbes Infect
December 2025
Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
While morphological examination is the most widely used for identification in clinical laboratories, PCR-sequencing and MALDI-TOF MS are emerging technologies in more financially-competent laboratories. However, mycological expertise, molecular biologists and/or expensive equipment are needed for these. Recently, artificial intelligence (AI), especially image recognition, is being increasingly employed in medicine for fast and automated disease diagnosis.
View Article and Find Full Text PDF[Update on acute leukemia of ambiguous lineage in 2023 - Recommendations of the French Society for Childhood and Adolescent Cancer and Leukemia (SFCE)].
Bull Cancer
October 2023
Service d'hématologie et immunologie pédiatrique, Hôpital Robert-Debré, Assistance publique des Hôpitaux de Paris (AP-HP), Université Paris-Cité, Paris, France. Electronic address:
Acute leukemias of ambiguous lineage (ALAL) represent between 3 and 5% of childhood AL. This term encompasses many subtypes of AL that have been defined according to the immunophenotypic profile based on the expression of various lineage markers. This classification has been modified and enriched during the last decade thanks to the improvement of molecular biology techniques, which have led to reconsider the ontogenic proximity existing between certain forms of ALAL.
View Article and Find Full Text PDFGerman radiation oncology's next generation: a web-based survey of young biologists, medical physicists, and physicians-from problems to solutions.
Strahlenther Onkol
December 2024
Young DEGRO Trial Group, Berlin, Germany.
Background: Radiation science is of utmost significance not only due to its growing importance for clinical use, but also in everyday life such as in radiation protection questions. The expected increase in cancer incidence due to an aging population combined with technical advancements further implicates this importance and results in a higher need for sufficient highly educated and motivated personnel. Thus, factors preventing young scientists and medical personnel from entering or remaining in the field need to be identified.
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