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Applying Results of Extended Genotyping to Management of Positive Cervicovaginal Human Papillomavirus Test Results: Enduring Guidelines.
J Low Genit Tract Dis
January 2025
Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Objective: The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of extended genotyping results in cervical cancer prevention programs.
Methods: Risks of cervical intraepithelial neoplasia grade 3 or worse were calculated using data obtained with the Onclarity HPV Assay from large cohorts. Management recommendations were based on clinical action thresholds developed for the 2019 American Society for Colposcopy and Cervical Pathology Risk-Based Management Consensus Guidelines.
An Azomethine Derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2) Ameliorated 7,12-dimethylbenz(a)anthracene-induced Mammary Carcinoma through Nrf2-Keap1-HO-1 Pathway.
Curr Med Chem
January 2025
Department of Biochemistry, School of Medicine, Case Western Reserve University, Woods building, W437, 2109 Adelbert Road, Cleaveland, Ohio, 44106, USA.
Aims: The aim of this study is the evaluation of an Azomethine derivative, BCS2, for its antioxidant and anti-tumor activities against mammary carcinoma through the Nrf2- Keap1-HO-1 pathway.
Background: The global prevalence of breast cancer is rising at an alarming rate. The facilitation of abnormal cell proliferation in mammary carcinoma occurs due to the disruption of signaling pathways that balance pro- and antioxidant status, thereby producing oxidative stress that disrupts genomic stability.
Green Tea Catechins and Skin Health.
Antioxidants (Basel)
December 2024
Tea Research Institute, Zhejiang University, #866, Yuhangtang Road, Hangzhou 310058, China.
Green tea catechins (GTCs) are a group of bioactive polyphenolic compounds found in fresh tea leaves ( (L.) O. Kuntze).
View Article and Find Full Text PDFPolyvinyl chloride (PVC), its additives, microplastic and human health: Unresolved and emerging issues.
Sci Total Environ
January 2025
Zero Waste Europe, Rue du Commerce 31, 1000 Brussels, Belgium.
Polyvinyl chloride (PVC), a commonly used plastic across Europe, poses a number of risks at various stages of its life cycle. The carcinogenicity of PVC monomer, the need to use high number and volume of problematic additives, the easiness of fragmentation compared to other thermoplastics, the high volume of use in everyday products and the resulting extent to which European population is potentially exposed to both microplastics and chemicals and, finally, continuous problems during waste management, have raised concerns about impacts of PVC on human health and the environment for decades. As far back as in 2000, the European Commission recognized that PVC causes a wide range of serious problems for the environment and human health.
View Article and Find Full Text PDFApplication of Monte Carlo simulation and artificial neural network model to probabilistic health risk assessment in fluoride-endemic areas.
Heliyon
December 2024
Department of Computer Science and Engineering, Anand Engineering College, Agra, India.
Groundwater contamination with fluoride is a considerable public health concern that affects millions of people worldwide. The rapid growth of urbanization has led to increase in groundwater contamination. The health risk assessment focuses on both acute and chronic health consequences as it investigates the extent and effects of fluoride exposure through contaminated groundwater.
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