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A missed Nobel: Dr Subhas Mukhopadhyay (1931-1981), the Father of Indian IVF.
J Med Biogr
August 2024
Bengal Infertility & Reproductive Therapy Hospital (BIRTH), Kolkata, West Bengal, India.
The Indian journey of assisted reproductive therapy began in Calcutta on 3 October 1978, when Dr Subhas Mukhopadhyay discovered the technique of in vitro fertilisation (IVF) only 67 days following the birth of the world's first IVF baby, Louise Brown in the United Kingdom by Edwards and Steptoe. While Edwards won the Nobel Prize in 2010 for his groundbreaking work, Mukhopadhyay, the man behind the genesis of 'Durga', India's first IVF baby, never received any recognition. Instead, he faced severe humiliation from his peers.
View Article and Find Full Text PDFEstablishing a biochemical understanding of the initiation of chromosome replication in bacteria.
Proc Natl Acad Sci U S A
June 2024
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
In the mid-1950s, Arthur Kornberg elucidated the enzymatic synthesis of DNA by DNA polymerase, for which he was recognized with the 1959 Nobel Prize in Physiology or Medicine. He then identified many of the proteins that cooperate with DNA polymerase to replicate duplex DNA of small bacteriophages. However, one major unanswered problem was understanding the mechanism and control of the initiation of chromosome replication in bacteria.
View Article and Find Full Text PDFA narrative review of imaging tools for imaging subgingival calculus.
Front Oral Maxillofac Med
March 2023
Material Science and Engineering Program, University of California, San Diego, CA, USA.
Article Synopsis
- The usual way to find tartar (subgingival calculus) on teeth is by using a tool called a periodontal probe, but it can sometimes make mistakes.
- This review looks at new, more accurate ways to detect tartar that can help stop gum disease.
- Techniques like periodontal endoscopy and optical coherence tomography show promise, but they might take longer and cost more to use than traditional methods.
[Development of CAR-T Cells Effective against Solid Tumors].
Gan To Kagaku Ryoho
May 2023
Dept. of Immunology, Yamaguchi University Graduate School of Medicine.
Traditionally, the 3 major standard treatments for cancers-surgery, chemotherapy, and radiation therapy-have been applied and have saved many lives. However, malignancies have been the leading cause of death in Japan for more than 40 years since 1981, and the trend is still accelerating. According to the statistics report from the Ministry of Health, Labour and Welfare, cancers accounted for 26.
View Article and Find Full Text PDFTopical reinforcement of the cervical mucus barrier to sperm.
Sci Transl Med
November 2022
Division of Glycoscience, Department of Chemistry, School of Engineering Science in Chemistry, Biotechnology and Health (CBH), AlbaNova University Center, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden.
Close to half of the world's pregnancies are still unplanned, reflecting a clear unmet need in contraception. Ideally, a contraceptive would provide the high efficacy of hormonal treatments, without systemic side effects. Here, we studied topical reinforcement of the cervical mucus by chitosan mucoadhesive polymers as a form of female contraceptive.
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