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http://dx.doi.org/10.1126/science.215.4529.116-a | DOI Listing |
EBioMedicine
January 2025
Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, New Cornerstone Science Foundation, Beijing, 100084, China. Electronic address:
Background: The widespread and evolution of RNA viruses, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights the importance of fast identification of virus subtypes, particularly in non-laboratory settings. Rapid and inexpensive at-home testing of viral nucleic acids with single-base resolution remains a challenge.
Methods: Topologically constrained DNA ring is engineered as substrates for the trans-cleavage of Cas13a to yield an accelerated post isothermal amplification.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the bone loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative.
View Article and Find Full Text PDFSci Data
January 2025
University of Antwerp - imec - IDLab, Department of Mathematics, Antwerp, 2000, Belgium.
As global fertilizer application rates increase, high-quality datasets are paramount for comprehensive analyses to support informed decision-making and policy formulation in crucial areas such as food security or climate change. This study aims to fill existing data gaps by employing two machine learning models, eXtreme Gradient Boosting and HistGradientBoosting algorithms to produce precise country-level predictions of nitrogen (N), phosphorus pentoxide (PO), and potassium oxide (KO) application rates. Subsequently, we created a comprehensive dataset of 5-arcmin resolution maps depicting the application rates of each fertilizer for 13 major crop groups from 1961 to 2019.
View Article and Find Full Text PDFSci Total Environ
January 2025
Environmental Economics (EnvEcon), Department of Engineering Management, Faculty of Business and Economics, University of Antwerp, Prinsstraat 13, 2000 Antwerp, Belgium; Flanders Make@UAntwerp, 2000 Antwerp, Belgium; NANOlight Centre of Excellence, Prinsstraat 13, 2000 Antwerp, Belgium. Electronic address:
Nutrient enrichment of water bodies can lead to eutrophication, which poses a global threat to freshwater ecosystems, affecting biodiversity and water quality. While human activities have accelerated eutrophication, climate change further complicates the dynamics of nutrient cycling and ecosystem responses. Here, we provide global, spatially explicit freshwater eutrophication characterization factors, at an annual resolution from 2021 up to 2099 based on eight different climate change scenarios.
View Article and Find Full Text PDFSe Pu
January 2025
Research Center for Eco-Environmental Engineering, Dongguan University of Technology, Dongguan 523808, China.
Halogenated organic pollutants (HOPs) have attracted considerable attention owing to their persistence, bioaccumulation, and toxicity. The development of methods to detect HOPs in fish is challenging owing to the compositional complexity of fish matrices, which contain high levels of lipids and relatively low concentrations of HOPs. In addition, the lipophilicity of most HOPs renders their extraction difficult.
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