Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.97.2522.404 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1 Cells.
Cells
February 2022
Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany.
Inhibition of the prolyl-4-hydroxylase domain (PHD) enzymes, leading to the stabilization of hypoxia-inducible factor (HIF) α as well as to the stimulation of erythropoietin (Epo) synthesis, is the functional mechanism of the new anti-anemia drug roxadustat. Little is known about the effects of roxadustat on the Epo-producing cell pool. To gain further insights into the function of PHD inhibitors, we characterized the abundance of mesenchymal stem cell (MSC)-like cells after roxadustat treatment of mice.
View Article and Find Full Text PDFIsolation, enrichment, and analysis of erythropoietins in anti-doping analysis by receptor-coated magnetic beads and liquid chromatography-mass spectrometry.
Anal Chem
December 2014
Center for Preventive Doping Research/Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
Human erythropoietin (hEPO) is an erythropoiesis stimulating hormone frequently employed in antianemia therapy. Its capability to increase the amount of red blood cells however makes hEPO and its derivatives also attractive to dishonest athletes aiming at an artificial and illicit enhancement of their endurance performance. A major objective of the international antidoping fight is the elimination of drug misuse and prevention of severe adverse effects caused by nontherapeutic administrations of highly potent drugs.
View Article and Find Full Text PDF[Case report: hookworm infection in a patient with severe anemia].
Turkiye Parazitol Derg
April 2010
Yüzüncü Yil Universitesi Tip Fakültesi, Parazitoloji Anabilim Dali, Van, Türkiye, Turkey.
Article Synopsis
- Laboratory tests confirmed severe iron deficiency anemia, and further stool analysis revealed a hookworm infection as the underlying cause.
- The patient improved significantly after receiving treatment for both the anemia and the parasitic infection, highlighting the need for health centers to check for intestinal parasites in cases of iron deficiency anemia.
On the white Wistar rats with alimentary dyslipidemia investigated influence 1-O-alkyl-glycerides ethers (AGE), received by a method of hydrolysis 1-O-alkyl-diacylglycerides from lipids of the squid Berryteuthis magister liver, on a lipid metabolism, hepatobiliary functions of liver, antioxidant systems and parameters of blood. Are revealed antioxidant, antianemia and immunoactive properties of AGE. AGE raise a level of glucose and activity of enzymes hepatobiliary systems in blood, interfere the decrease of a cholesterol in blood.
View Article and Find Full Text PDF[Experimental studies on antianimia effect of shengxuesu].
Zhongguo Zhong Yao Za Zhi
June 2003
Pharmacology Department, Shanxi Institute for Drug Control, Taiyuan 030001, Shanxi, China.
Objective: Using animal anemia models to observe the antianemia effect of Shengxuesu, and to afford an experimental basis for preventing and treating anemia.
Method: Rat model of iron deficiency induced by denutrition and mouse model of nemorrhagic anemia by blood lefting were established. Indices of hemoglobin(HB), red blood cell count(RBC), hematocrit(HCT), mean corpuscular hemoglobin count(MCHC), serum iron(SI), serum ferritin (SF) and total iron-binding capacity(TIBC) were monitored.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!