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Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals.
Elife
December 2024
Centre for Developmental Neurobiology, King's College London, London, United Kingdom.
The expression of eukaryotic genes relies on the precise 3'-terminal cleavage and polyadenylation of newly synthesized pre-mRNA transcripts. Defects in these processes have been associated with various diseases, including cancer. While cancer-focused sequencing studies have identified numerous driver mutations in protein-coding sequences, noncoding drivers - particularly those affecting the cis-elements required for pre-mRNA cleavage and polyadenylation - have received less attention.
View Article and Find Full Text PDFRHPS4 Targeted the G-Quadruplex of the Gene of to Inhibit Viral Proliferation.
J Agric Food Chem
November 2024
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Small molecules targeting G-quadruplexes (G4s) in viruses could inhibit viral proliferation. The 1a protein of (CMV) act as RNA-dependent RNA polymerase (RdRp) that plays a crucial role in regulating the replication of CMV. In this study, four putative G4 sequences (CMV PQS1-PQS4) in the genetic coding region of CMV were identified, and three of them (PQS2, PQS3, and PQS4) were confirmed to fold into G4 structures.
View Article and Find Full Text PDFCharacterization of Hibiscus Chlorotic Ringspot Virus-Derived vsiRNAs from Infected Hibiscus rosa-sinensis in China.
Plant Pathol J
October 2024
Key Laboratory of Landscape Plants with Fujian and Taiwan Characteristics of Fujian Colleges and Universities, School of Biological Sciences and Biotechnology, Minnan Normal University, Zhangzhou 363000, China.
Article Synopsis
- Progress has been made in understanding the relationship between Hibiscus rosa-sinensis and hibiscus chlorotic ringspot virus (HCRSV), but many interactions are still not well understood.
- HCRSV infection in H. rosa-sinensis was confirmed using various advanced techniques, and the virus was found to have a 3,909 nucleotide long genome with features similar to other closely related viruses.
- The study identified specific viral small interfering RNAs (vsiRNAs) derived from HCRSV, discovering that they predominantly come from the positive-strand RNA and exhibit unique patterns in distribution which may relate to the secondary structures of the viral genome.
study of a new theranostic smart niosomal nanostructure for direct delivery of docetaxel via anti-PSMA aptamer.
Heliyon
September 2024
Center for Advanced Technologies, Adam Mickiewicz University, Uniwersytetu Poznańskiego 10, 61-614, Poznań, Poland.
In this study, a novel quantum dot (QD)-labeled specific anti-prostate-specific membrane antigen (PSMA) aptamer sequence was conjugated to a pH-responsive niosomal particle platform for delivery of docetaxel (DTX) components. The target cells were overexpressed PSMA. This strategy can minimize the systemic toxicity prevalent in DTX.
View Article and Find Full Text PDFPrecise Insertion of AttB Sequences in Goat Genome Using Enhanced Prime Editor.
Int J Mol Sci
August 2024
Key Laboratory of Livestock Biology, Northwest A&F University, Yangling 712100, China.
Prime editor, an editing tool based on the CRISPR/Cas9 system, allows for all 12 types of nucleotide exchanges and arbitrary indels in genomic sequences without the need for inducing DNA double-strand breaks. Despite its flexibility and precision, prime editing efficiency is still low and hindered by various factors such as target sites, editing types, and the length of the primer binding site. In this study, we developed a prime editing system by incorporating an RNA motif at the 3' terminal of the pegRNA and integrating all twin prime editor factors into a single plasmid.
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