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Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most prevalent type of senile dementia affecting more than 6 million Americans in 2023. Most of these AD cases are sporadic or late-onset AD with unclear etiology. Recent clinical trials on antibody drug clearing Ab plagues in brain show modest benefits of slowing down cognitive decline.
View Article and Find Full Text PDFThis longitudinal study aimed to examine the long-term effects of Reminiscing and Emotion Training (RET), child maltreatment, and the COVID-19 pandemic on maternal elaboration and sensitive guidance during reminiscing. RET was developed to improve maternal elaborative and emotionally sensitive reminiscing among maltreating mothers of preschool-aged children. Of the original 248 mothers and their preschool-aged children who participated in the trial of RET, which included 165 families with maltreatment who were randomized to receive RET ( = 83) or a case management community standard condition (CS, = 82), and a group of demographically similar families with no history of child maltreatment, nonmaltreatment comparison (NC, = 83), 166 families participated in an assessment 5 years postintervention (Time 5; T5) at which children were aged 8-12 years.
View Article and Find Full Text PDFComplex memories induced by intracranial electrical brain stimulation are related to complex networks.
Cortex
December 2024
Brain Research and Cognition Center (CerCo), CNRS, UMR5549, France; University of Toulouse, Faculty of Health, France.
The precise and fleeting moment of rich recollection triggered by an environmental cue is difficult to reproduce in the lab. However, epilepsy patients can experience sudden reminiscences after intracranial electrical brain stimulation (EBS). In these cases, the transient brain state related to the activation of the engram and its conscious perception can be recorded using intracerebral EEG (iEEG).
View Article and Find Full Text PDFPower of reminiscence.
Br J Community Nurs
January 2025
Senior Lecturer (cancer and palliative care), Birmingham City University.
Treatments for Depression for Older Adults Living in Long-Term Care: A Systematic Review and Network Meta-Analysis.
J Am Med Dir Assoc
December 2024
Department of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:
Objective: To assess the comparative efficacy of interventions on depressive symptoms and disorders in older adults living in long-term care (LTC).
Design: Systematic review and network meta-analysis.
Setting And Participants: Older adults living in LTC or equivalent settings.
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