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Semaglutide restores astrocyte-vascular interactions and blood-brain barrier integrity in a model of diet-induced metabolic syndrome.
Diabetol Metab Syndr
January 2025
Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation-Fiocruz, Campus Maré. Centro de Pesquisa, Inovação e Vigilância em Covid-19 e Emergências Sanitárias. Endereço: Av. Brasil, 4036-Bloco 2. Manguinhos, Rio de Janeiro, RJ, CEP 21040-361, Brazil.
Introduction: Metabolic syndrome (MetS) is a metabolic disorder related to obesity and insulin resistance and is the primary determinant of the development of low-intensity chronic inflammation. This continuous inflammatory response culminates in neuroimmune-endocrine dysregulation responsible for the metabolic abnormalities and morbidities observed in individuals with MetS. Events such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in individuals with MetS may contribute to the activation of the innate immune response, which compromises cerebral microcirculation and the neurovascular unit, leading to the onset or progression of neurodegenerative diseases.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Southampton, Southampton, United Kingdom.
Background: The neuroimmune response, characterised by the proliferation and activation of microglial cells, is a driver of Alzheimer's disease (AD). However, the extent of immune cell infiltration and interactions in the human AD brain are yet to be established in detail. While microglial cells are at the centre of this neuroimmune response, recent research has explored the possibility of peripheral immune cell involvement, typically focusing on T-cell infiltration.
View Article and Find Full Text PDFNeuroimmune signalling pathways in chronic rhinosinusitis with nasal polyps.
Curr Opin Allergy Clin Immunol
February 2025
Specialist Allergy and Clinical Immunology, Rhinology Section, Royal National ENT and Eastman Dental Hospitals, University College London Hospitals NHS Foundation Trust, London, UK.
Purpose Of Review: To evaluate the role of neuroimmune signalling pathways in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP).
Recent Findings: The sinonasal mucosa is densely infiltrated by immune cells and neuronal structures that share an intimate spatial relationship within tissue compartments. Together, such neuroimmune units play a critical role in airway defence and homeostatic function.
The neuroimmune mechanism of pain induced depression in psoriatic arthritis and future directions.
Biomed Pharmacother
December 2024
Rheumatology Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China. Electronic address:
Patients suffering from psoriatic arthritis (PsA) often experience depression due to chronic joint pain, which significantly hinders their recovery process. However, the relationship between these two conditions is not well understood. Through a review of existing studies, we revealed that certain neuroendocrine hormones and neurotransmitters are involved in the neuroimmune interactions related to both PsA and depression.
View Article and Find Full Text PDFUnraveling Alzheimer's disease: insights from single-cell sequencing and spatial transcriptomic.
Front Neurol
December 2024
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
Article Synopsis
- Alzheimer's disease (AD) is a progressive condition that leads to cognitive decline, with a focus on memory and executive functions.
- Recent advancements in single-cell sequencing and spatial transcriptomics help uncover the complex cellular interactions involved in AD, highlighting distinct cell types that drive neuroinflammation and degeneration.
- The integration of these advanced technologies is essential for developing targeted therapies and personalization in medicine, emphasizing the importance of collaboration across disciplines to improve treatments and patient care.
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