Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 143
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: Attempt to read property "Count" on bool
Filename: helpers/my_audit_helper.php
Line Number: 3100
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Background: To validate estimates of completeness of cancer ascertainment obtained by the flow method.
Methods: We generated a computer simulation of patient-level cancer registration processes, based loosely on the age distribution and survival of colorectal carcinoma patients, and utilizing a mixture of 'cured' and 'killed' subjects with an age-dependent fraction of 'cured' cases. The simulated data were then used in an analysis of completeness using the flow method. Validation of the simulation process was based on similarity of outputs to those obtained using real data, and validation of the flow method on its ability to correctly estimate the known proportion of cases in the simulated data which would never be registered.
Results: We successfully generated realistic data and have shown that completeness estimated by the flow method is close to the true value, whereas another method of estimating completeness (Ajiki's) was shown to be strongly biased. We also modelled what happens to completeness estimates when a new registry is set up.
Conclusions: When its assumptions are met (steady state for incidence, survival and stable population structure), the flow method works well but is biased for cancers with good survival. Further research is required to assess the robustness of the method when these conditions are not met.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1093/pubmed/fdm053 | DOI Listing |
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