Background: The mechanisms causing age-dependent changes in left ventricular (LV) structure and function are not completely understood. Matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) constitute one important proteolytic pathway affecting LV remodeling. However, whether these determinants of extracellular matrix (ECM) composition change as a function of age has not been examined in an aging population free of clinically significant cardiovascular disease.
Methods And Results: Subjects (n = 77, age 20-90 years) with no evidence of cardiovascular disease underwent echocardiography and measurement of plasma MMP-2, 7, 8, and 9 and TIMP-1, 2, and 4 (enzyme-linked immunosorbent assay). As subject age increased, volume/mass ratio decreased and mitral E/A ratio decreased. As subject age increased, MMP-2 increased (from 1188 +/- 99 ng/mL to 1507 +/- 76 ng/mL), MMP-7 increased (from 1.2 +/- 0.1 ng/mL to 3.1 +/- 0.6 ng/mL), MMP-9 decreased (from 29 +/- 7 ng/mL to 8 +/- 2 ng/mL), and TIMP-1, 2, and 4 increased (from 728 +/- 46 ng/mL to 1093 +/- 73 ng/mL, from 34 +/- 5 ng/mL to 53 +/- 6 ng/mL, and from 1.26 +/- 0.22 ng/mL to 2.34 +/- 0.30 ng/mL, respectively) (all P < .05). There were significant correlations between decreased LV volume/mass and E/A ratio and increased MMP-7 and TIMP-1 and 4.
Conclusions: MMPs and TIMPs changed as a function of age in the absence of clinically significant cardiovascular disease. These age-dependent alterations in MMP and TIMP profiles favor ECM accumulation and were associated with concentric remodeling and decreased LV diastolic function. Because of these age-dependent changes in this proteolytic system, the superimposition of disease processes such as myocardial infarction or hypertensive heart disease in the older subject may result in different myocardial ECM remodeling than that seen in a younger subject.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698433 | PMC |
| http://dx.doi.org/10.1016/j.cardfail.2007.04.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria.
Front Neurosci
January 2025
Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Introduction: Dysarthria is a motor speech disorder frequently associated with subcortical damage. However, the precise roles of the subcortical nuclei, particularly the basal ganglia and thalamus, in the speech production process remain poorly understood.
Methods: The present study aimed to better understand their roles by mapping neuroimaging, behavioral, and speech data obtained from subacute stroke patients with subcortical lesions.
Vocal Fold Vibration Associated With Inspiratory Phonation-An Acoustic and Electroglottographic Study.
J Voice
December 2024
Department of Duquesne-China Health Institute, John G. Rangos Sr. School of Health Sciences, Duquesne University, Pittsburgh, PA; Speech Science Laboratory, Faculty of Education, The University of Hong Kong, Hong Kong SAR, China.
Article Synopsis
- The study focused on inspiratory phonation (IP) and its differences from expiratory phonation (EP) in terms of voice quality and glottal vibratory characteristics.
- Acoustic and electroglottographic analyses were conducted on the vowel /i/ produced by 43 vocally healthy adults to assess voice metrics like fundamental frequency and jitter.
- Results showed distinct changes in glottal vibration during IP, highlighting its clinical significance and the need for more research to understand its role in diagnosing and treating voice disorders.
Nonsurgical treatment of bilateral vocal fold paralysis: a case study of voice training combined with acupuncture.
Acupunct Med
October 2024
Department of Rehabilitation, The Third Xiangya Hospital, Central South University, Changsha, China.
Introduction: Consistency of liquid food plays an important role in managing patients with dysphagia, which can be objectively evaluated by using IDDSI Flow Test and consistometry. The present study established the relationship between IDDSI Flow Test and consistometric measures, and examined the measurement limitations of each test associated with thickened liquids prepared using starch-based and xanthan gum-based thickening agents.
Methods: Thirteen thickened liquid samples of consistency ranging from IDDSI Level 1 (mildly thick) to Level 3 (moderately thick) were prepared using starch-based and xanthan gum-based thickeners.
Effect of Face Masks on Voice Quality Associated with Young and Older Chinese Adult Speakers.
J Voice
June 2024
Duquesne-China Health Institute, John G. Rangos, Sr. School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania. Electronic address:
Objectives: Face masks have become important after the pandemic, but the change in voice when wearing a face mask is still unclear. The study investigated the effect of face masks on the acoustic and perceptual characteristics of voice quality associated with young and older Chinese adults.
Methods: Voice samples of the sustained vowel /a/ and continuous speech produced by 44 older and 61 young adults with and without an ASTM level-3 surgical face mask were recorded and analyzed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!