Introduction: In this study, we evaluated and compared treatment effects and long-term soft-tissue profile changes in patients treated with extraction of 4 first premolars and with a nonextraction protocol.
Methods: Cephalometric records of 98 patients were evaluated. For half (n = 49) of the patients, treatment included the extraction of 4 first premolars; the other 49 patients had no premolar extractions. The groups were evaluated before treatment (T1), at the end of treatment (T2), and at least 4 years postretention (T3).
Results: At T1, the extraction group had more protrusive lower lips than the nonextraction group, as measured by the Z-angle. At T2, the Z-angles had improved in both groups and were not significantly different. During treatment, upper lip vermilion and superior thicknesses increased, whereas lower lip vermilion thickness decreased in both groups. Except for lower lip inferior thickness, which increased significantly in the nonextraction group, no other soft-tissue differences were significant. Significant growth of the nose occurred during from T1 to T2 in both groups, and there was a tendency for the incisors in both groups to return to pretreatment values. The nose also continued to grow during that period.
Conclusions: Overall, the soft-tissue facial profile measurements for both extraction and nonextraction samples were similar at T3, and there were no clinically significant correlations between hard- and soft-tissue variables at T1, T2, and T3.
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http://dx.doi.org/10.1016/j.ajodo.2005.08.045 | DOI Listing |
Tree Physiol
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Forest Tree Breeding Center, Forestry and Forest Products Research Institute, Forest Research and Management Organization, Hitachi, Ibaraki 319-1301, Japan.
The selection of plant genotypes characterized by wellness and stable growth under drought-stress conditions amid ongoing climate change is an important challenge in forest tree breeding. The introduction of molecular markers will enable efficient selection of breeding materials that are resistant to drought stress in forest trees as well as in crop species. Japanese cedar, Cryptomeria japonica, the most dominant forest species in Japan, grows well on mesic sites and is characterized by intraspecific variation in its drought-stress response.
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Computational Biology Lab, Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, 603203, Tamil Nadu, India.
JAK1, a key regulator of multiple oncogenic pathways, is a sought-out target, and its expression in immune cells and tumour-infiltrating lymphocytes (TILs) is associated with a favorable prognosis in breast cancer. JAK1 activates IL-6 via ERBB2 receptor tyrosine kinase signalling and promotes metastatic cancer and STAT3 activation in breast cancer cells. Hence, targeting JAK1 in breast cancer is being explored as a potential therapeutic strategy.
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Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India.
Snake envenomation presents a significant global health challenge, especially in rural areas of tropical and subtropical regions. Traditional antivenom therapies face limitations related to efficacy, availability, and specificity, prompting a need for novel approaches. Recent advancements in omics technologies, particularly metabolomics and proteomics, have enhanced our understanding of snake venom composition, toxicity, and potential therapeutic strategies.
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Department of Pediatrics, Division of General Pediatrics and Adolescent Health, University of Minnesota.
Despite the rapid changes in the use of communication technologies in families, research on how parents use communication technologies to stay connected with adolescents has been limited. Grounded in interdisciplinary theories in family and media studies, the primary aim of this study was to identify and describe unique patterns of parent-adolescent communication using parent reports of communication. Further, we considered whether parent-adolescent closeness was associated with parent-adolescent communication patterns.
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