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Role of the X Chromosome in Alzheimer Disease Genetics.
JAMA Neurol
October 2024
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.
Importance: The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD.
Objectives: To perform the first large-scale X chromosome-wide association study (XWAS) of AD.
Design, Setting, And Participants: This was a meta-analysis of genetic association studies in case-control, family-based, population-based, and longitudinal AD-related cohorts from the US Alzheimer's Disease Genetics Consortium, the Alzheimer's Disease Sequencing Project, the UK Biobank, the Finnish health registry, and the US Million Veterans Program.
Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria.
Immunity
August 2024
Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD, USA; Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Electronic address:
Many infections, including malaria, are associated with an increase in autoantibodies (AAbs). Prior studies have reported an association between genetic markers of susceptibility to autoimmune disease and resistance to malaria, but the underlying mechanisms are unclear. Here, we performed a longitudinal study of children and adults (n = 602) in Mali and found that high levels of plasma AAbs before the malaria season independently predicted a reduced risk of clinical malaria in children during the ensuing malaria season.
View Article and Find Full Text PDFUncovering lupus nephritis-specific genes and the potential of TNFRSF17-targeted immunotherapy: a high-throughput sequencing study.
Front Immunol
March 2024
Laboratory for Tumor Immunology, The First Hospital of Jilin University, Changchun, China.
Article Synopsis
- Lupus nephritis (LN) is a serious condition that can happen when someone has lupus, and this study wanted to find new genes to help treat it.
- The researchers looked at blood samples from LN patients and compared them to healthy people and other lupus patients without LN to find 1493 special genes related to LN.
- They found that a drug named IBI379 could help treat LN by targeting a specific gene (TNFRSF17) and causing harmful cells to die without hurting other important cells.
MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification.
Front Immunol
February 2024
Affiliated Cancer Hospital, Dalian University of Technology, Dalian, China.
Background: Immunohistochemistry (IHC) is a widely used laboratory technique for cancer diagnosis, which selectively binds specific antibodies to target proteins in tissue samples and then makes the bound proteins visible through chemical staining. Deep learning approaches have the potential to be employed in quantifying tumor immune micro-environment (TIME) in digitized IHC histological slides. However, it lacks of publicly available IHC datasets explicitly collected for the in-depth TIME analysis.
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