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Specific patterns of sensory activity may induce plastic remodeling of neurons and the communication network they form in the adult mammalian brain. Among the indicators for the initiation of neuronal remodeling is the expression of immediate early genes (IEGs). The IEGs c-fos and egr-1 encode transcription factors. Following spectrally and temporally precisely defined unilateral electrical intracochlear stimulation (EIS) that corresponded in strength to physiological acoustic stimuli and lasted for 2 h under anesthesia, we characterized those neuronal cell types in ventral (VCN) and dorsal cochlear nucleus (DCN), lateral superior olive (LSO) and central nucleus of the inferior colliculus (CIC) of the rat brain that expressed IEGs. We found that EIS affected only specific types of neurons. Whereas sub-populations of glutamatergic and glycinergic cells responded in all four regions, GABAergic neurons failed to do so except in DCN. Combining immunocytochemistry with axonal tracing, neurons participating in major ascending pathways, commissural cells of VCN and certain types of neurons of the descending auditory system were seen to respond to EIS with IEG expression. By contrast, principal LSO cells projecting to the contralateral CIC as well as collicular efferents of the DCN did not. In total, less than 50% of the identified neurons turned up expression of the IEGs studied. The pattern of IEG expression caused by unilateral EIS led us to suggest that dominant sensory activity may quickly initiate a facilitation of central pathways serving the active ear at the expense of those serving the unstimulated ear.
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http://dx.doi.org/10.1016/j.expneurol.2007.06.016 | DOI Listing |
Exp Neurol
December 2024
Department of Neurology, Henry Ford Health System, Detroit, MI 48202, United States of America. Electronic address:
Dendritic and axonal plasticity, which mediates neurobiological recovery after a stroke, critically depends on the mitochondrial function of neurons. To investigate, in vivo, neuronal mitochondrial function at the stroke recovery stage, we employed Mito-tag mice combined with cerebral cortical infection of AAV9 produced from plasmids carrying Cre-recombinase controlled by two neuronal promoters, synapsin-I (SYN1) and calmodulin-kinase IIa to induce expression of a hemagglutinin (HA)-tagged enhanced green fluorescence protein (EGFP) that localizes to mitochondrial outer membranes of SYN1 positive (SYN) and CaMKIIa positive (CaMKIIa) neurons. These mice were then subjected to permanent middle cerebral artery occlusion (MCAO) and sacrificed 14 days post stroke.
View Article and Find Full Text PDFJ Physiol
December 2024
Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Although mammals resist both acute weight loss and weight gain, the neural circuitry mediating bi-directional defense against weight change is incompletely understood. Global constitutive deletion of the melanocortin-3-receptor (MC3R) impairs the behavioural response to both anorexic and orexigenic stimuli, with MC3R knockout mice demonstrating increased weight gain following anabolic challenges and increased weight loss following anorexic challenges (i.e.
View Article and Find Full Text PDFAnal Chem
December 2024
Instituto de Biomedicina y Genética Molecular, Unidad de Excelencia, University of Valladolid-CSIC, Valladolid 47003, Spain.
Lipid rafts are liquid-ordered domains in which specific enzymes and receptors are located. These membrane platforms play crucial roles in a variety of signaling pathways. Alterations in the lipid environment, such as those elicited by oxidative stress, can lead to important functional disruptions in membrane proteins.
View Article and Find Full Text PDFBrain
December 2024
School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.
Convergent data, across species, paint a compelling picture of the critical role of the gut and its resident microbiota in several brain functions and disorders. The chemicals mediating communication along these sophisticated highways of the brain-gut-microbiome (BGM) axis include both microbiota metabolites and classical neurotransmitters. Amongst the latter, GABA is fundamental to brain function where it mediates the majority of neuronal inhibition.
View Article and Find Full Text PDFPediatr Dev Pathol
December 2024
Department of Human Genetics, National Institute of Pediatrics, Mexico City, Mexico.
Neuronal ceroid lipofuscinosis type 2 (CLN2) results from biallelic pathogenic variants in the gene, leading to deficient activity of the lysosomal enzyme tripeptidyl peptidase 1. We report an autopsy case of CLN2 characterized at molecular level. The patient exhibited a spectrum of neurologic symptoms including epilepsy, behavioral alterations, cognitive regression, motor impairment, and visual loss.
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