Aim: To investigate the effect of IL-4 on the expression of ABCG2 in lung adencarcinoma cell lines.
Methods: The ABCG2 mRNA and protein expression was determined by semi-quantitative RT-PCR and Western blot respectively.
Results: The ABCG2 mRNA and protein was detectable in lung adencarcinoma cell lines A549 and SPC-A-1. But IL-4 stimulation did not significantly affect the ABCG2 mRNA and protein expression in lung adencarcinoma cell lines.
Conclusion: IL-4 does not regulate ABCG2 expression in human lung adencarcinoma cell lines.
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