The purpose of this study was to report the results of unicompartmental knee arthroplasty in patients 60 years or younger for a period long enough to be statistically significant. In a cohort of 1173 unicompartmental knee prostheses implanted between 1991 and 2006, 161 knees from 158 patients 60 years or younger at the time of surgery who had 5 to 14 years of follow-up were reviewed. The Genesis unicompartmental knee replacement (Smith & Nephew, Memphis, Tenn) with the metal-back or full-poly design was implanted in these patients. The Knee Society score at most recent follow-up was 94.02, and average function score was 93.76. Survivorship for the entire cohort was 94.50% at 10 years and 88.48% at 12 years.

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